(1 reference)-
- 抗原 See all SCARB1 抗体
- SCARB1 (Scavenger Receptor Class B, Member 1 (SCARB1))
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适用
- 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This SCARB1 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Neutralization (Neut)
- 过滤
- 0.2 μm filtered
- 克隆位点
- 3D12
- Top Product
- Discover our top product SCARB1 Primary Antibody
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anti-Scavenger Receptor Class B, Member 1 (SCARB1) (AA 21-100) antibody
SCARB1 适用: 人, 大鼠, 小鼠, 小鸡 WB, ELISA, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Scavenger Receptor Class B, Member 1 (SCARB1) (AA 450-509), (C-Term) antibodySCARB1 适用: 人, 大鼠, 小鼠 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Scavenger Receptor Class B, Member 1 (SCARB1) (AA 33-440) antibodySCARB1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Scavenger Receptor Class B, Member 1 (SCARB1) (Internal Region) antibodySCARB1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Scavenger Receptor Class B, Member 1 (SCARB1) (AA 238-250) antibodyVerified SCARB1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Scavenger Receptor Class B, Member 1 (SCARB1) (AA 1-100) antibodySCARB1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Scavenger Receptor Class B, Member 1 (SCARB1) (AA 33-443) antibodySCARB1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Scavenger Receptor Class B, Member 1 (SCARB1) (AA 114-163) antibodySCARB1 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Scavenger Receptor Class B, Member 1 (SCARB1) (C-Term) antibodyVerified SCARB1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Scavenger Receptor Class B, Member 1 (SCARB1) (AA 72-101), (N-Term) antibodySCARB1 适用: 人 WB 宿主: 兔 Polyclonal RB41754 unconjugated
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- 应用备注
- For flow cytometry and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For neutralization of biological activity in vitro dilutions have to be made according to the amounts of SR-BI to be inactivated.
- 限制
- 仅限研究用
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- 缓冲液
- PBS containing 0.1 % bovine serum albumin.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- 有效期
- 12 months
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: "Expression and function of class B scavenger receptor type I on both apical and basolateral sides of the plasma membrane of polarized testicular Sertoli cells of the rat." in: Development, growth & differentiation, Vol. 46, Issue 3, pp. 283-98, (2004) (PubMed).
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: "Expression and function of class B scavenger receptor type I on both apical and basolateral sides of the plasma membrane of polarized testicular Sertoli cells of the rat." in: Development, growth & differentiation, Vol. 46, Issue 3, pp. 283-98, (2004) (PubMed).
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- 抗原
- SCARB1 (Scavenger Receptor Class B, Member 1 (SCARB1))
- 别名
- Scavenger Receptor Bi (SCARB1 产品)
- 别名
- cb1015 antibody, SCARB1 antibody, Scarb1 antibody, CD36L1 antibody, CLA-1 antibody, CLA1 antibody, HDLQTL6 antibody, SR-BI antibody, SRB1 antibody, AI120173 antibody, CD36 antibody, Cd36l1 antibody, Cla-1 antibody, Cla1 antibody, D5Ertd460e antibody, Hdlq1 antibody, Hlb398 antibody, SR-B1 antibody, SRBI antibody, Srb1 antibody, mSR-BI antibody, scavenger receptor class B, member 1 antibody, scavenger receptor class B member 1 antibody, scarb1 antibody, SCARB1 antibody, Scarb1 antibody, CpipJ_CPIJ014332 antibody, CpipJ_CPIJ019101 antibody
- 背景
- Monoclonal antibody 3D12 reacts with rat class B scavenger receptor type I (SR-BI). Scavenger receptors have been studied primarily for their ability to bind and internalize modified lipoproteins. They have been found in the development of atherosclerosis and other macrophage-associated functions. Scavenger receptors also function as pattern recognition receptors for a wide variety of pathogens. This finding indicates a potential role in host defense. SR-BI belongs together with CD36 to the class B scavenger receptor family. SR-BI is a multiligand membrane protein existing in various organs such as the liver and various cell types such as endothelial cells, macrophages, brain cells, Leydig cells and Sertoli cells. SR-BI has been found as a receptor for phospholipids, free and (lipo)protein-bound ApoE, lipid-bound ApoA-I, HDL, hypochlorite- modified LDL and more. In liver, the PDZK-1 (and possible other PDZ domains) of SR-BI has been found to be essential for cell surface expression and, hence, reverse cholesterol transport. In the brain, the presence of SR-BI seems to be involved in the uptake of oxidatively modified lipoproteins and beta- amyloid protein complexed with ApoE, suggesting SR-BI to be an important tool for studies on neurodegenerative disorders. In the testis, SR-BI is expressed in two somatic cell types: Leydig cells and Sertoli cells. SR-BI functions at least partly as a phosphatidyl serine receptor (PSR), enabling Sertoli cells to recognize and phagocytose apoptotic spermatogenic cells at all stages of differentiation. Monoclonal antibody 3D12 blocks the biological activity of rat SR-BI. For example, it inhibits the ability of SR-BI to mediate the corporation of lipids of HDL by SR-BI expressing cells.
- 途径
- Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Lipid Metabolism, SARS-CoV-2 Protein Interactome
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