(1 reference)-
- 抗原 See all TLR6 抗体
- TLR6 (Toll-Like Receptor 6 (TLR6))
-
适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This TLR6 antibody is un-conjugated
-
应用范围
- Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP)
- 过滤
- 0.2 μm filtered
- 克隆位点
- TLR6-127
- Top Product
- Discover our top product TLR6 Primary Antibody
-
anti-Toll-Like Receptor 6 (TLR6) (AA 301-400) antibody
TLR6 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 6 (TLR6) (AA 393-423) antibodyTLR6 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 6 (TLR6) (AA 722-753) antibodyTLR6 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 6 (TLR6) (AA 32-586) antibodyTLR6 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 6 (TLR6) (AA 608-796) antibodyTLR6 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 6 (TLR6) (AA 408-424) antibody (PE)TLR6 适用: 人 FACS 宿主: 小鼠 Monoclonal 86B1153-2 PE
anti-Toll-Like Receptor 6 (TLR6) (AA 32-200) antibodyTLR6 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 6 (TLR6) (AA 722-753), (C-Term) antibodyTLR6 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 6 (TLR6) (AA 1-30) antibodyTLR6 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 6 (TLR6) (C-Term) antibodyTLR6 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- For immunoprecipitation, immunofluorescence staining and flow cytometry dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For neutralization of biological activity, in vitro dilutions have to be made according to the amounts of TLR6 to be inactivated.
- 限制
- 仅限研究用
-
- 缓冲液
- PBS, containing 0.1 % bovine serum albumin.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- 有效期
- 12 months
-
-
: "Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 3, pp. 1566-73, (2005) (PubMed).
-
: "Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 3, pp. 1566-73, (2005) (PubMed).
-
- 抗原
- TLR6 (Toll-Like Receptor 6 (TLR6))
- 别名
- Toll-Like Receptor 6 (TLR6 产品)
- 别名
- TLR1 antibody, TLR16 antibody, CD286 antibody, TLR-6 antibody, toll-like receptor 1 family member A antibody, toll like receptor 6 antibody, toll-like receptor 6 antibody, TLR1A antibody, TLR6 antibody, Tlr6 antibody
- 背景
- The monoclonal antibody TLR6.127 reacts with the human Toll-like receptor 6 (TLR6). Toll-like receptors (TLRs) are highly conserved throughout evolution. They play an essential role in initiating the innate immune response against infectious pathogens. In Drosophila, toll is required for anti-fungal response, while the related 18-wheeler is involved in antibacterial defence. In humans, ten members of the TLR family protein (TLR1 to TLR10) have been identified. TLRs recognize a wide variety of pathogen-associated molecular patterns from bacteria, viruses, and fungi and elicit a wide array of antimicrobial responses. Among TLRs, TLR6 is expressed on the cell surface of monocytes, monocyte- derived immature dendritic cells (iDCs), and neutrophils, but not on B, T or natural killer (NK) cells. Human TLR6 is a 796-aa type l transmembrane protein that is 74 % identical with mouse. It contains an N-terminal signal peptide, 19 tandemly repeated extracellular leucine-rich motifs, and a cytoplasmic domain called Toll/IL-1R homology domain, as seen in other TLRs. TLR6 function has been studied mainly in mouse cells. Constitutive expression of TLR6 activates both the nuclear factor kappa-B (NFK- B) and Jun N-terminal kinase (JNK) pathways. Studies in human cells revealed that TLR6 and TLR2 colocalize at the plasma membrane of monocytes. Human TLR6 recognizes diacylated lipoprotein and peptidoglycan at the cell surface cooperatively with human TLR2. Thus, coexpression of TLR2 and TLR6 at the cell surface is crucial for recognition of diacylated lipopeptide and peptideoglycan and subsequent cellular activation in human cells. Aliases CD286
- 途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
-
You are here:
