AOC3 抗体
(2 references)Quick Overview for AOC3 抗体 (ABIN2192061)
抗原
See all AOC3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
交叉反应 （详细）
- Cross reactivity: Rat : Yes
-
过滤
- 0.2 μm filtered
-
亚型
- IgG1
-
-
anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) (AA 27-190) antibody
AOC3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) (AA 613-640) antibodyAOC3 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22029 unconjugated
anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) (AA 27-259) antibodyAOC3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) (AA 1-763) antibodyAOC3 适用: 人 WB, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) (AA 351-450) antibodyAOC3 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 4B8 unconjugated
anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) (Internal Region) antibodyAOC3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) antibodyAOC3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) antibodyAOC3 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) antibodyAOC3 适用: 人 WB, ELISA, IHC, IF, FACS, IP, IAC, Inh 宿主: 兔 Chimeric TK8-14 unconjugated Recombinant Antibody
anti-Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3) antibodyAOC3 适用: 人, 小鼠, 大鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- For immunohistochemistry and flow cytometry, dilutions to be used depend on detection system chemistry, , applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. Positive Ax cells stably transfected with VAP-1 cDNA. (Ref. 1) VAP control Negative Mock transfected Ax cells. (Ref. 1) control
-
限制
- 仅限研究用
-
-
-
缓冲液
- PBS, containing 0.1 % bovine serum albumin.
-
储存条件
- 4 °C
-
储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
-
-
-
: "PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein 1 targeting peptide 68Ga-DOTAVAP-P1: comparison with 18F-FDG." in: European journal of nuclear medicine and molecular imaging, Vol. 37, Issue 10, pp. 1918-25, (2010) (PubMed).
: "Blockade of vascular adhesion protein-1 inhibits lymphocyte infiltration in rat liver allograft rejection." in: The American journal of pathology, Vol. 165, Issue 6, pp. 1993-2001, (2004) (PubMed).
-
: "PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein 1 targeting peptide 68Ga-DOTAVAP-P1: comparison with 18F-FDG." in: European journal of nuclear medicine and molecular imaging, Vol. 37, Issue 10, pp. 1918-25, (2010) (PubMed).
-
- AOC3 (Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3))
-
别名
- Vascular Adhesion Protein-1
-
背景
- The monoclonal antibody 174-5 recognises human Vascular Adhesion Protein-1 (VAP-1), which is a glycosylated homodimeric membrane protein consisting of two 90 kDa subunits connected by disulfide bonds. It contains a short N-terminal cytoplasmic tail, a single membrane-spanning domain and a large extracellular part. A soluble form of VAP-1 (sVAP-1) has been described, which presumably results from the proteolytic cleavage of membrane-bound VAP-1. Structurally VAP-1 belongs to enzymes called semicarbamizide-sensitive amine oxidases, which contain copper as a cofactor. These enzymes deaminate primary amines in a reaction producing hydrogen peroxide, aldehyde, and ammonia. VAP-1 is present in endothelial cells, smooth muscle cells, adipocytes, and in follicular dendritic cells. In endothelial cells the majority of VAP-1 is stored within intracellular granules and translocated to the surface upon inflammation where it regulates leukocyte tissue infiltration. Furthermore, the end- products formed by VAP-1 can also regulate leukocyte migration by signaling effects, have insulin-like effects in energy metabolism, and can cause vascular damage by direct cytotoxicity. Elevated sVAP- 1serum levels have been described in several inflammatory diseases as well as colorectal cancer. Moreover, diminished insulin secretion appears to increase the concentration of soluble VAP-1 in plasma. Therefore, VAP-1 might be an interesting diagnostic marker as well therapeutic target for modulating inflammation.The monoclonal antibody 174-5 has been shown to cross-react with rat VAP- 1 and to inhibit lymphocyte infiltration in rat liver allograft rejection. Aliases membrane primary amine oxidase, AOC3, SSAO Immunogen Purified vessels from human peripheral lymph nodes (ref 1)
-
途径
- Feeding Behaviour
抗原
-
