(2 references)-
- 抗原 See all GRF2 (RAPGEF1) 抗体
- GRF2 (RAPGEF1) (Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1))
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适用
- 人
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This GRF2 antibody is un-conjugated
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应用范围
- Immunoprecipitation (IP), Immunoassay (IA)
- 过滤
- 0.2 μm filtered
- 克隆位点
- 9
- Top Product
- Discover our top product RAPGEF1 Primary Antibody
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anti-Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1) (AA 1-110) antibody
RAPGEF1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D10 unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1) (AA 844-1095) antibodyRAPGEF1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1) (AA 536-569) antibodyRAPGEF1 适用: 人 WB 宿主: 兔 Polyclonal RB52924 unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1) antibodyRAPGEF1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1) (AA 1-1095) antibodyRAPGEF1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1) (AA 780-1035) antibodyRAPGEF1 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1) (C-Term) antibodyRAPGEF1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1) (AA 22-40) antibodyRAPGEF1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1) antibodyRAPGEF1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1) (AA 866-915) antibodyRAPGEF1 适用: 人, 小鼠, 犬, 猴, Cow, 豚鼠, 马, Pig, 非洲爪蟾, Bat, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- of monoclonal anti-C3 antibodies to characterise the fragments of C3 that are found on erythrocytes. Vox Sang 1983, 45: 367 4. Chaplin, H et al, Further studies of the C3g component of the alpha 2D fragment of human C3. Clin Exp Immunol 1983, 51: 639 5. Mollnes, T et al, Activation of the third component of complement (C3) detected by a monoclonal anti-C3'g' neoantigen antibody in a one-step enzyme immunoassay. J Immunol Methods 1987, 101: 201
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- 有效期
- 12 months
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: "Breakdown of C3 after complement activation. Identification of a new fragment C3g, using monoclonal antibodies." in: The Journal of experimental medicine, Vol. 156, Issue 1, pp. 205-16, (1982) (PubMed).
: "Three rat monoclonal antibodies to human C3." in: Immunology, Vol. 41, Issue 3, pp. 503-15, (1981) (PubMed).
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: "Breakdown of C3 after complement activation. Identification of a new fragment C3g, using monoclonal antibodies." in: The Journal of experimental medicine, Vol. 156, Issue 1, pp. 205-16, (1982) (PubMed).
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- 抗原
- GRF2 (RAPGEF1) (Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1))
- 别名
- c3g (RAPGEF1 产品)
- 别名
- C3G antibody, GRF2 antibody, Link-GEFII antibody, 4932418O06Rik antibody, Grf2 antibody, RAPGEF1 antibody, C3G-1 antibody, C3G-2 antibody, C3g antibody, rapgef1 antibody, zgc:56372 antibody, Rap guanine nucleotide exchange factor 1 antibody, Rap guanine nucleotide exchange factor like 1 antibody, Rap guanine nucleotide exchange factor (GEF) 1 antibody, Rap guanine nucleotide exchange factor 1 S homeolog antibody, Rap guanine nucleotide exchange factor (GEF) 1b antibody, RAPGEF1 antibody, RAPGEFL1 antibody, Rapgef1 antibody, rapgef1.S antibody, rapgef1 antibody, rapgef1b antibody, Rapgefl1 antibody
- 背景
- The monocolonal antibody 9 (also known as YB2/90-5-20) reacts with a neoantigen on iC3, iC3b, C3dg and C3g. C3g itself however is a small fragment probably not formed in vivo. The complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. Activation products of the complement cascade contain neo-epitopes that are not present in the individual native components. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg/mL. An inherited deficiency of C3 predisposes the person to frequent bacterial infections. C3 fragments are deposited in tissues at sites of antibody-mediated immunopathology. In ulcerative colitis and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. Proteolysis by C3-convertases results in the cleavage of C3 into C3a and C3b. C3b becomes attached to immune complexes and is further cleaved into iC3b and C3f. iC3b is further processed into C3c and C3dg. C3dg can be cleaved into C3d and C3g though this does not occur in plasma. The monoclonal antibody 9 recognizes iC3b, C3dg and C3g in plasma. The monoclonal antibody does not recognize C3 or C3b.
- 途径
- Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor
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