(6 references)-
- 抗原 See all PI3 抗体
- PI3 (Peptidase Inhibitor 3, Skin-Derived (PI3))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This PI3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoassay (IA)
- 过滤
- 0.2 μm filtered
- 克隆位点
- TRAB2O
- Top Product
- Discover our top product PI3 Primary Antibody
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anti-Peptidase Inhibitor 3, Skin-Derived (PI3) antibody
PI3 适用: 人, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Peptidase Inhibitor 3, Skin-Derived (PI3) (AA 1-117) antibodyPI3 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2G20 unconjugated
anti-Peptidase Inhibitor 3, Skin-Derived (PI3) (AA 23-117) antibodyPI3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Peptidase Inhibitor 3, Skin-Derived (PI3) antibodyPI3 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Peptidase Inhibitor 3, Skin-Derived (PI3) (AA 1-117) antibodyPI3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G9 unconjugated
anti-Peptidase Inhibitor 3, Skin-Derived (PI3) (AA 41-117) antibodyPI3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Peptidase Inhibitor 3, Skin-Derived (PI3) (AA 1-117) antibodyPI3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Peptidase Inhibitor 3, Skin-Derived (PI3) (N-Term) antibodyPI3 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Peptidase Inhibitor 3, Skin-Derived (PI3) (AA 36-85) antibodyPI3 适用: 人, Cow WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- For immunohistology and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. For Western blotting it is recommended to use non-reducing conditions.
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- 有效期
- 12 months
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: "Dynamic alteration of human beta-defensin 2 localization from cytoplasm to intercellular space in psoriatic skin." in: Journal of molecular medicine (Berlin, Germany), Vol. 80, Issue 10, pp. 678-84, (2002) (PubMed).
: "Development and application of monoclonal antibodies against SKALP/elafin and other trappin family members." in: Archives of dermatological research, Vol. 293, Issue 7, pp. 343-9, (2001) (PubMed).
: "The trappin gene family: proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core." in: The Biochemical journal, Vol. 340 ( Pt 3), pp. 569-77, (1999) (PubMed).
: "Expression of SKALP/elafin during wound healing in human skin." in: Archives of dermatological research, Vol. 288, Issue 8, pp. 458-62, (1997) (PubMed).
: "Constitutive and inducible expression of SKALP/elafin provides anti-elastase defense in human epithelia." in: The Journal of clinical investigation, Vol. 98, Issue 6, pp. 1389-99, (1996) (PubMed).
: "Demonstration of skin-derived antileukoproteinase (SKALP) and its target enzyme human leukocyte elastase in squamous cell carcinoma." in: The Journal of pathology, Vol. 174, Issue 2, pp. 121-9, (1994) (PubMed).
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: "Dynamic alteration of human beta-defensin 2 localization from cytoplasm to intercellular space in psoriatic skin." in: Journal of molecular medicine (Berlin, Germany), Vol. 80, Issue 10, pp. 678-84, (2002) (PubMed).
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- 抗原
- PI3 (Peptidase Inhibitor 3, Skin-Derived (PI3))
- 别名
- Elafin/skalp (PI3 产品)
- 别名
- ESI antibody, SKALP antibody, WAP3 antibody, WFDC14 antibody, cementoin antibody, trappin-2 antibody, TRAPPIN-2 antibody, elafin antibody, peptidase inhibitor 3 antibody, peptidase inhibitor 3, skin-derived (SKALP) antibody, PI3 antibody
- 背景
- Elafin is an epithelial proteinase inhibitor also known under various other names such as Skin-derived Anti leukoproteinase (SKALP) and Elastase-Specific Inhibitor (ESI). Elafin belongs to the Trappin gene family and was given the systematic name Trappin-2. The Trappin family is defined by a N-terminal transglutaminase substrate domain and a C-terminal four disulphide core. Trappins have been suggested to play a role in the regulation of inflammation and in protection against tissue damage in stratified epithelia. Elafin is an inhibitor of leukocyte elastase and proteinase-3 and is a substrate for transglutaminases. The protein is constitutively expressed in various epithelia including hair follicles, oesophagus, vagina and oral cavity. Elafin is not present in normal human skin but is strongly induced during inflammation as in psoriasis and wound healing. Antibodies to Elafin can be used to evaluate the effects of treatment of psoriasis since its expression is significantly correlated with clinical scores. Antibodies to Elafin have also been succesfully used to study differentiation in squamous cell carcinoma of the head-and-neck region, oesophagus and skin. It is also shown that Elafin possesses antimicrobial activity against gram-positive and gram-negative bacteria. TRAB2O recognises all known Trappins via the GQDPVK epitope. TRAB2O shows strong reaction with human native full-length Elafin/SKALP and a weaker reaction with fully processed Elafin/SKALP (C-terminal 57 aa). For detection of fully processed Elafin/SKALP (C-terminal 57 aa) we advise to use HM2063. The antibody is cross reactive with Trappin family members of other species with GQDPVK epitope.
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