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- 抗原 See all IL1R2 抗体
- IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This IL1R2 antibody is un-conjugated
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应用范围
- Immunoassay (IA)
- 过滤
- 0.2 μm filtered
- 克隆位点
- 6G5
- Top Product
- Discover our top product IL1R2 Primary Antibody
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- 应用备注
- The antibody can be used for immuno assays.
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- 有效期
- 12 months
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High circulating levels of the IL-1 type II decoy receptor in critically ill patients with sepsis: association of high decoy receptor levels with glucocorticoid administration." in: Journal of leukocyte biology, Vol. 72, Issue 4, pp. 643-9, (2002) (PubMed).
: "Regulation of inhibitory pathways of the interleukin-1 system." in: Annals of the New York Academy of Sciences, Vol. 840, pp. 338-51, (1998) (PubMed).
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High circulating levels of the IL-1 type II decoy receptor in critically ill patients with sepsis: association of high decoy receptor levels with glucocorticoid administration." in: Journal of leukocyte biology, Vol. 72, Issue 4, pp. 643-9, (2002) (PubMed).
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- 抗原
- IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))
- Abstract
- IL1R2 产品
- 别名
- CD121b antibody, CDw121b antibody, IL-1R-2 antibody, IL-1RT-2 antibody, IL-1RT2 antibody, IL1R2c antibody, IL1RB antibody, Il1r-2 antibody, IL-1R2 antibody, interleukin 1 receptor type 2 antibody, interleukin 1 receptor, type II antibody, interleukin-like antibody, IL1R2 antibody, Il1r2 antibody, KK34 antibody
- 背景
- The antibody reacts specificly with Human IL-1 R II. The IL-1 system includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1 R I and IL-1 R II) and the IL-1 receptor accessory protein. The IL-1 R II is part of the antagonistic IL-1 mechanism. It is also known as decoy receptor and is a non signaling molecule which functions by capturing IL-1 and preventing it from interacting with the signalling IL-1 R I. The decoy IL-1 R II can after binding to IL-1 also recruit the IL-1 receptor accessory protein and thus inhibit by coreceptor competition. Further a soluble form of IL-1 R II exists which is shed, a process in which matrix metalloproteases have been found to play a role, by various cells including monocytes, polymorphonuclear cells, B cells and fibroblasts.
- 途径
- NF-kappaB Signaling
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