SLPI 抗体 (Biotin)
(6 references)-
- 抗原 See all SLPI 抗体
- SLPI (Secretory Leukocyte Peptidase Inhibitor (SLPI))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This SLPI antibody is conjugated to Biotin
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
- 过滤
- 0.2 μm filtered
- 克隆位点
- 31
- Top Product
- Discover our top product SLPI Primary Antibody
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anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) (AA 20-131) antibody
SLPI 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) (AA 26-132) antibodySLPI 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) (AA 33-132) antibodySLPI 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3C6 unconjugated
anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) antibodySLPI 适用: 人 WB, ELISA, IHC, IP, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal 31 unconjugated
anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) antibodySLPI 适用: 人 WB, IP, IHC (p), FACS 宿主: 小鼠 Monoclonal 31 unconjugated
anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) (N-Term) antibodySLPI 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) (Center) antibodySLPI 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) (AA 11-60) antibodySLPI 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) (AA 1-132) antibodySLPI 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Secretory Leukocyte Peptidase Inhibitor (SLPI) (AA 26-132) antibodySLPI 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- For immunohistochemistry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
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: "Secretory leukocyte protease inhibitor inhibits neutrophil apoptosis." in: Respirology (Carlton, Vic.), Vol. 16, Issue 2, pp. 300-7, (2011) (PubMed).
: "Overexpression of a secretory leukocyte protease inhibitor in human gastric cancer." in: International journal of cancer. Journal international du cancer, Vol. 123, Issue 8, pp. 1787-96, (2008) (PubMed).
: "WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung." in: Respiratory research, Vol. 7, pp. 61, (2006) (PubMed).
: "Human neutrophil defensins and secretory leukocyte proteinase inhibitor in squamous metaplastic epithelium of bronchial airways." in: Inflammation research : official journal of the European Histamine Research Society ... [et al.], Vol. 53, Issue 6, pp. 230-8, (2004) (PubMed).
: "Assessment of oral transmission using cell-free human immunodeficiency virus-1 in mice reconstituted with human peripheral blood leucocyte." in: Immunology, Vol. 109, Issue 2, pp. 271-82, (2003) (PubMed).
: "Induction of SLPI (ALP/HUSI-I) in epidermal keratinocytes." in: The Journal of investigative dermatology, Vol. 111, Issue 6, pp. 996-1002, (1999) (PubMed).
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: "Secretory leukocyte protease inhibitor inhibits neutrophil apoptosis." in: Respirology (Carlton, Vic.), Vol. 16, Issue 2, pp. 300-7, (2011) (PubMed).
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- 抗原
- SLPI (Secretory Leukocyte Peptidase Inhibitor (SLPI))
- 别名
- Slpi (SLPI 产品)
- 别名
- ALK1 antibody, ALP antibody, BLPI antibody, HUSI antibody, HUSI-I antibody, MPI antibody, WAP4 antibody, WFDC4 antibody, MATN4 antibody, SLPI antibody, ckpi antibody, secretory leukocyte peptidase inhibitor antibody, antileukoproteinase antibody, SLPI antibody, Slpi antibody, LOC102174044 antibody
- 背景
- The monoclonal antibody 31 recognizes secretory leukocyte proteinase inhibitor (SLPI). SLPI was identified as an alarm reactant and expression is induced by inflammatory factors like LPS, IL1β, TNFα and neutrophils elastase. SLPI is a relatively small basic antiprotease of 11.7 kDa and is a cationic non-glycosylated protein consisting of 107amino acids. SLPI has a high affinity for the neutrophil serine proteinases, elastase and cathepsin G. Orthologues of SLPI have been found in mice, rate, pigs and sheep. It consists of two highly similar WAP ('whey acid protein')/four-disulphide core domains. SLPI contain 16 cysteine residues which assemble into eight disulphide bridges (four in each WAP domain). SLPI is constitutively expressed at many mucosal surfaces and is produced by a variety of epithelial cells, including respiratory, intestinal and amniotic epithelia. Expression is also detected in mast cells, neutrophils and macrophages. Expression of SLPI gene is significantly increased by progesterone and by the pro-inflammatory cytokines TNF-α and IL1-β. Although SLPI has been shown to inhibit a spectrum of proteases (including HNE, cathepsin G, trypsin, chymotrypsin and chymase), its main action in this regard is likely to be the inhibition of elastase, as indicated by its low dissociation constant and favourable kinetics of inhibition for this enzyme. SLPI has been described in several body fluids like seminal fluid, bronchial fluids, cervical fluids and saliva. It has been found to be antibacterial, antifungal, anti-retroviral, and to have an important role in mucosal defence. SLPI might also facilitate tumor spread, contributing to wound healing, is elevated in sepsis and levels seem to correlate with oral candidiasis in HIV-1 positive patients. The reactivity of the antibody 31 with isolated domains of SLPI was evaluated using domains obtained by cleavage using partial acidic hydrolysis. Therefore, monoclonal antibody 31 recognizes also other SLPI cleavage products. Aliases human seminal plasma inhibitor I (HUSI-I), cervix uterine secretion inhibitor (CUSI), bronchial inhibitor (BI), antileukoprotease (ALP) and mucous proteinase inhibitor (MPI), Immunogen SLPI purified from sputum
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