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ITGB1 抗体

Name: ITGB1 抗体
Brand: antibodies-online
SKU: ABIN2191900
Availability: OutOfStock

ITGB1 适用: 人 FACS, Func 宿主: 小鼠 Monoclonal BV7 unconjugated

Beta-1 integrin expression on HUVEC cells. (ITGB1 抗体)

FACS

1 image

(5 references)

产品编号 ABIN2191900

发货至: 中国

Datasheet as PDF

抗原 See all ITGB1 抗体

ITGB1 (Integrin beta 1 (ITGB1))
适用
210

96

78

21

18

18

17

10

9

8

7

3

2

2

2

2

2

1

1

1

1
人
宿主
156

66

14

6

2

1
小鼠
Compatible Secondaries
克隆类型
145

95

1
单克隆
标记
109

23

22

15

10

7

6

6

4

4

4

4

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1
This ITGB1 antibody is un-conjugated
应用范围
124

109

76

54

33

27

27

26

25

18

13

7

5

4

3

3

3

1

1

1

1
Flow Cytometry (FACS), Functional Studies (Func)

过滤

0.2 μm filtered

克隆位点

BV7

Top Product

Discover our top product ITGB1 Primary Antibody
anti-Integrin beta 1 (ITGB1) (AA 25-100) antibody
ITGB1 适用: 人, 小鼠, 大鼠, 绵羊, 兔 WB, FACS, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated

anti-Integrin beta 1 (ITGB1) antibody
ITGB1 适用: 人 WB, FACS, ELISA, IHC 宿主: 小鼠 Monoclonal 3B6 unconjugated

anti-Integrin beta 1 (ITGB1) (AA 140-383) antibody
ITGB1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Integrin beta 1 (ITGB1) antibody
ITGB1 适用: 人, Pig, 犬 WB, FACS, IP 宿主: 小鼠 Monoclonal MEM-101A unconjugated

anti-Integrin beta 1 (ITGB1) antibody (PE)
ITGB1 适用: 人, Pig, 犬 FACS 宿主: 小鼠 Monoclonal MEM-101A PE

anti-Integrin beta 1 (ITGB1) (AA 297-380) antibody
ITGB1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Integrin beta 1 (ITGB1) antibody
ITGB1 适用: 人 WB, FACS, ELISA, IHC, IF 宿主: 兔 Monoclonal 32A10 unconjugated Recombinant Antibody

anti-Integrin beta 1 (ITGB1) (AA 454-714) antibody
ITGB1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Integrin beta 1 (ITGB1) (AA 140-383) antibody
ITGB1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C2 unconjugated

anti-Integrin beta 1 (ITGB1) (C-Term) antibody
ITGB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

For, flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. Positive HT-29 colon carcinoma, Endothelial cells control

限制

仅限研究用
缓冲液

PBS, containing 0.1 % bovine serum albumin

储存条件

4 °C

储存方法

Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
Bozzo, Lombardi, Santoro, Canonico: "Involvement of beta(1) integrin in betaAP-induced apoptosis in human neuroblastoma cells." in: Molecular and cellular neurosciences, Vol. 25, Issue 1, pp. 1-8, (2004) (PubMed).

Hofmann, Bernabei, Crociani, Cherubini, Guasti, Pillozzi, Lastraioli, Polvani, Bartolozzi, Solazzo, Gragnani, Defilippi, Rosati, Wanke, Olivotto, Arcangeli: "HERG K+ channels activation during beta(1) integrin-mediated adhesion to fibronectin induces an up-regulation of alpha(v)beta(3) integrin in the preosteoclastic leukemia cell line FLG 29.1." in: The Journal of biological chemistry, Vol. 276, Issue 7, pp. 4923-31, (2001) (PubMed).

Palmieri, Camardella, Ulivi, Guasco, Manduca: "Trimer carboxyl propeptide of collagen I produced by mature osteoblasts is chemotactic for endothelial cells." in: The Journal of biological chemistry, Vol. 275, Issue 42, pp. 32658-63, (2000) (PubMed).

Martel, Vignoud, Dupé, Frachet, Block, Albigès-Rizo: "Talin controls the exit of the integrin alpha 5 beta 1 from an early compartment of the secretory pathway." in: Journal of cell science, Vol. 113 ( Pt 11), pp. 1951-61, (2000) (PubMed).

Martìn-Padura, Bazzoni, Zanetti, Bernasconi, Elices, Mantovani, Dejana: "A novel mechanism of colon carcinoma cell adhesion to the endothelium triggered by beta 1 integrin chain." in: The Journal of biological chemistry, Vol. 269, Issue 8, pp. 6124-32, (1994) (PubMed).
抗原

ITGB1 (Integrin beta 1 (ITGB1))

别名

beta-1 Integrin (ITGB1 产品)

别名

CD29 antibody, FNRB antibody, GPIIA antibody, MDF2 antibody, MSK12 antibody, VLA-BETA antibody, VLAB antibody, 4633401G24Rik antibody, AA409975 antibody, AA960159 antibody, ENSMUSG00000051907 antibody, Fnrb antibody, Gm9863 antibody, gpIIa antibody, cd29 antibody, fnrb antibody, gpiia antibody, itgb1 antibody, mdf2 antibody, msk12 antibody, vla-beta antibody, vlab antibody, itgb1-a antibody, itgb1-b antibody, integrin subunit beta 1 antibody, integrin beta 1 (fibronectin receptor beta) antibody, integrin subunit beta 1 S homeolog antibody, integrin beta 1 antibody, integrin subunit beta 1 L homeolog antibody, ITGB1 antibody, Itgb1 antibody, itgb1.S antibody, LOC100009173 antibody, itgb1.L antibody

背景

The monoclonal antibody BV7 recognizes human ß1-integrin. Beta-1 integrin is a ubiquitously expressed ~89 kDa type I transmembrane protein functioning as receptor when heterodimerized with one alpha subunit. It belongs to the integrin beta chain family consisting of four different genes, encoding multiple β-integrins via alternative splicing. Ligand-recognition depends on the composition of the heterodimer: either collagen, fibronectin, VCAM1, laminin, cytotactin, osteopontin, epiligrin, thrombospondin and CSPG4 can bind to the integrin-complex. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When associated with α7, β1-integrin regulates cell adhesion and laminin matrix deposition. BV7 is active on HT-29 colon carcinoma cells and on HCCP-2998 tumor cells. It is involved in promoting endothelial cell motility and angiogenesis. Furthermore, β1-integrin plays a mechanistic adhesive role during telophase, and is required for the successful completion of cytokinesis. Upon activation integrins in general, including β1-integrin, are known to exhibit global structural rearrangements and exposure of ligand binding sites. β1-integrin modulation is of importance in tissue repair and regeneration. In cultured primary hippocampal neurons, astrocytes and tissues, cell surface expression of amyloid beta fibrils (key hallmark of Alzheimer's disease) selectively co-localized with β1-integrin. Preincubation of cells with antibodies against β1-integrin, as well as α1-integrin, greatly enhanced amyloid beta-induced apoptosis, indicating a protective role for integrins in apoptosis. The monoclonal antibody BV7 does not recognize α5β1 complex and not the cytoplasmic part of the β1-subunit. Monoclonal antibody BV7 is active on HT-29 colon carcinoma cells and on HCCP-2998 tumor cells. BV7 binds to several other tumor cells (MG3 osteosarcoma, A375 melanoma, MHCC- 1410 and Lovo colon carcinoma) but does not affect adhesion to endothelial cells. Aliases CD29, fibronectin receptor subunit beta, VLA-4 subunit beta Immunogen Human umbilical vein EC

途径

Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex, SARS-CoV-2 Protein Interactome