(2 references)-
- 抗原 See all Complement C4 (C4) 抗体
- Complement C4 (C4) (Complement 4 (C4))
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This Complement C4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应 （详细）
- Cross reactivity: C4b : Yes, C4d : Yes
- 过滤
- 0.2 μm filtered
- 克隆位点
- 16D2
- 亚型
- IgG2a
- Top Product
- Discover our top product C4 Primary Antibody
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anti-Complement 4 (C4) (AA 1450-1723) antibody
C4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement 4 (C4) (AA 975-1336) antibodyC4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement 4 (C4) (AA 701-800) antibodyC4 适用: 人 IF (p), IF (cc), ELISA, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Complement 4 (C4) (AA 126-366) antibodyC4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement 4 (C4) (AA 1428-1660) antibodyC4 适用: 小鸡 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement 4 (C4) (Internal Region) antibodyC4 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Complement 4 (C4) (AA 1450-1723) antibodyC4 适用: 小鼠 FACS 宿主: 兔 Polyclonal unconjugated
anti-Complement 4 (C4) (AA 1419-1737) antibodyC4 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- For immunohistochemistry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Positive T-cell regions of mouse spleen control
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
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: "Synergistic deposition of C4d by complement-activating and non-activating antibodies in cardiac transplants." in: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 7, Issue 11, pp. 2605-14, (2007) (PubMed).
: "Anti-DNA autoreactivity in C4-deficient mice." in: European journal of immunology, Vol. 32, Issue 9, pp. 2672-9, (2002) (PubMed).
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: "Synergistic deposition of C4d by complement-activating and non-activating antibodies in cardiac transplants." in: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 7, Issue 11, pp. 2605-14, (2007) (PubMed).
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- 抗原
- Complement C4 (C4) (Complement 4 (C4))
- 别名
- c4 (C4 产品)
- 别名
- C4B1 antibody, C4B12 antibody, C4B2 antibody, C4B3 antibody, C4B5 antibody, C4BD antibody, C4B_2 antibody, C4F antibody, CH antibody, CO4 antibody, CPAMD3 antibody, C4 antibody, C4A2 antibody, C4A3 antibody, C4A4 antibody, C4A6 antibody, C4AD antibody, C4S antibody, CPAMD2 antibody, RG antibody, C4-1 antibody, C4b antibody, C4-2 antibody, Slp antibody, Ss antibody, complement C4B (Chido blood group) antibody, complement C4A (Rodgers blood group) antibody, complement component 4A (Rodgers blood group) antibody, complement 4 antibody, complement component 4A antibody, complement component 4B (Chido blood group) antibody, C4B antibody, C4A antibody, C4a antibody, C4 antibody, C4b antibody
- 背景
- The monoclonal antibody 16D2 recognizes mouse complement factor C4, formerly known as Gg protein, which consists of an alpha-, beta-, and gamma-chain. The classical pathway of complement and the Mannose binding lectin activation pathway converge at C4. C1s, MASP-1 and MASP-2 cleave C4 resulting in the formation of C4a and C4b. Subsequently, C4b can be cleaved to C4c and C4d by other serum enzymes. The monoclonal antibody 16D2 reacts with intact C4, C4b and C4d. C4 is an acute phase protein that is produced by hepatocytes, monocytes and intestinal epithelial cells and can be used in experimental animals as a marker for activation of the classical complement pathway. Recent studies have demonstrated an association between graft rejection and C4d deposition in a mouse model for cardiac transplantation. Aliases Complement component 4 Immunogen Thymocytes decorated with Thy-1 antibody and complement components
- 途径
- Complement System
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