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IL1RAP 抗体 (AA 251-350)

IL1RAP 适用: 小鼠 ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2176996
发货至: 中国
  • 抗原 See all IL1RAP 抗体
    IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))
    抗原表位
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 251-350
    适用
    • 31
    • 12
    • 3
    小鼠
    宿主
    • 33
    • 4
    克隆类型
    • 33
    • 4
    多克隆
    标记
    • 25
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL1RAP antibody is un-conjugated
    应用范围
    • 25
    • 11
    • 10
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    小鼠
    预测反应
    Human,Rat
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human IL1RAP/IL1R3
    亚型
    IgG
    Top Product
    Discover our top product IL1RAP Primary Antibody
  • 应用备注
    ELISA 1:500-1000
    IHC-P 1:200-400
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))
    别名
    IL1RAP (IL1RAP 产品)
    别名
    IL1RAP antibody, il-1racp antibody, il-racp antibody, il1r3 antibody, C3orf13 antibody, IL-1RAcP antibody, IL1R3 antibody, 6430709H04Rik antibody, AI255955 antibody, AV239853 antibody, IL-1RAcp antibody, Il1racpb antibody, interleukin 1 receptor accessory protein antibody, IL1RAP antibody, il1rap antibody, il-1racp antibody, Il1rap antibody
    背景

    Synonyms: IL1R3, C3orf13, IL-1RAcP, Interleukin-1 receptor accessory protein, IL-1 receptor accessory protein, Interleukin-1 receptor 3, IL-1R-3, IL-1R3, IL1RAP

    Background: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone, binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

    基因ID
    3556
    UniProt
    Q9NPH3
    途径
    NF-kappaB Signaling, Growth Factor Binding
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