IL2RG 抗体 (AA 51-150) (Biotin)
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- 抗原 See all IL2RG 抗体
- IL2RG (Interleukin 2 Receptor, gamma (IL2RG))
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抗原表位
- AA 51-150
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适用
- 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This IL2RG antibody is conjugated to Biotin
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应用范围
- Western Blotting (WB), ELISA
- 交叉反应
- 人, 大鼠
- 预测反应
- Mouse,Dog,Cow,Pig
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human IL-2R gamma
- 亚型
- IgG
- Top Product
- Discover our top product IL2RG Primary Antibody
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anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 51-150) antibody
IL2RG 适用: 人, 大鼠 WB, FACS, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 23-262) antibodyIL2RG 适用: 人 WB, FACS, ELISA, IHC, ICC, Neut 宿主: 小鼠 Monoclonal 4A8F2 unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 76-101), (N-Term) antibodyIL2RG 适用: 人 WB, FACS, IF 宿主: 兔 Polyclonal RB22117 unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 23-262) antibodyIL2RG 适用: 人 WB, ELISA, ICC, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 23-263) antibodyIL2RG 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) antibody (APC)IL2RG 适用: 人, 犬 FACS 宿主: 大鼠 Monoclonal TUGh4 APC
anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 75-230) antibodyIL2RG 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) (N-Term) antibodyIL2RG 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) antibodyIL2RG 适用: 人, 犬 FACS 宿主: 大鼠 Monoclonal TUGh4 unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 23-260) antibodyIL2RG 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:300-5000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- IL2RG (Interleukin 2 Receptor, gamma (IL2RG))
- 别名
- IL-2R gamma (IL2RG 产品)
- 别名
- Ab2-183 antibody, Cd132 antibody, CD132 antibody, CIDX antibody, IL-2RG antibody, IMD4 antibody, P64 antibody, SCIDX antibody, SCIDX1 antibody, [g]c antibody, gamma(c) antibody, gc antibody, interleukin 2 receptor subunit gamma antibody, interleukin 2 receptor subunit gamma L homeolog antibody, interleukin 2 receptor, gamma chain antibody, IL2RG antibody, il2rg.L antibody, Il2rg antibody
- 背景
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Synonyms: P64, CIDX, IMD4, CD132, SCIDX, IL-2RG, SCIDX1, Cytokine receptor common subunit gamma, Interleukin-2 receptor subunit gamma, IL-2 receptor subunit gamma, IL-2R subunit gamma, gammaC, IL2RG
Background: Interleukin 2 (IL2) receptor gamma chain (IL5212R gamma) is a cell surface glycoprotein expressed by a variety of leukocytes including T cells, B cells, NK cells, monocytes, macrophages, and neutrophils. IL2R gamma is also known as CD132, common cytokine receptor gamma chain, and gamma c. IL2R gamma forms complexes with other cell surface proteins including CD25 (IL2R alpha), CD122 (IL2R beta), CD124 (IL4R alpha), CD127 (IL7R), and others. IL2R gamma complexed with other cell surface proteins forms receptors for the cytokines IL2, IL4, IL7, IL9, and IL15. Acting through the IL2R gamma containing complexes, these cytokines regulate lymphocyte development and activation. Chemical cross linking experiments reveal that IL2R gamma is able to bind cytokines only when complexed with these other cell surface proteins. In addition to interacting with other cell surface glycoproteins, IL2R gamma associates with several cytoplasmic tyrosine kinases including JAK3 (Janus Kinase 3), JAK1, Syc, and Lyc. Cytokine binding to the IL2R gamma containing receptor complexes activates these tyrosine kinases. Once activated, these tyrosine kinases phosphorylate their associated receptors, creating docking sites for signaling molecules such as PI 3 kinase. The activated tyrosine kinases also phosphorylate downstream regulators including STAT3 (Signal Transducer and Activator of Transcription 3), STAT5, and STAT6. The various cytokines that bind to IL2R gamma containing receptor complexes exert their effects through unique repertoires of cytoplasmic signaling molecules. IL2, IL7, and IL9 exert their effects through cascades, which activate STAT3 and STAT5, while IL4 activates STAT6. IL2 and IL15 exert their effects through cascades, which activate the MAP kinase cascade. IL7 exerts its effects through a cascade that results in VDJ immunoglobulin gene rearrangement.
- 基因ID
- 3561
- UniProt
- P31785
- 途径
- JAK/STAT Signaling, Growth Factor Binding
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