HCST 抗体 (AA 19-48) (Cy5)
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- 抗原 See all HCST 抗体
- HCST (Hematopoietic Cell Signal Transducer (HCST))
- 抗原表位
- AA 19-48
- 适用
- 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HCST antibody is conjugated to Cy5
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- 交叉反应
- 人, 大鼠
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human HCST
- 亚型
- IgG
- Top Product
- Discover our top product HCST Primary Antibody
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anti-Hematopoietic Cell Signal Transducer (HCST) (AA 19-48) antibody
HCST 适用: 人, 大鼠 WB, FACS, IF (p), IF (cc), ELISA, IHC (fro), IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- HCST (Hematopoietic Cell Signal Transducer (HCST))
- 别名
- Hcst (HCST 产品)
- 别名
- DAP10 antibody, KAP10 antibody, PIK3AP antibody, Dap10 antibody, HCST antibody, dap10 antibody, dap10-A antibody, hcst antibody, hcsta antibody, kap10 antibody, pik3ap antibody, hematopoietic cell signal transducer antibody, hematopoietic cell signal transducer L homeolog antibody, HCST antibody, Hcst antibody, hcst antibody, hcst.L antibody
- 背景
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Synonyms: DAP10, KAP10, PIK3AP, Hematopoietic cell signal transducer, DNAX-activation protein 10, Membrane protein DAP10, Transmembrane adapter protein KAP10, HCST, UNQ587/PRO1157
Background: Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells, this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs), these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells, indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells.
- 基因ID
- 10870
- UniProt
- Q9UBK5
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