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ALOX15 抗体 (AA 581-662) (AbBy Fluor® 647)

ALOX15 适用: 人, 大鼠, 小鼠 FACS, IF (cc), IF (p) 宿主: 兔 Polyclonal AbBy Fluor® 647
产品编号 ABIN2169714
发货至: 中国
  • 抗原 See all ALOX15 抗体
    ALOX15 (Arachidonate 15-Lipoxygenase (ALOX15))
    抗原表位
    • 15
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 581-662
    适用
    • 56
    • 24
    • 20
    • 2
    • 2
    • 2
    • 2
    • 1
    人, 大鼠, 小鼠
    宿主
    • 48
    • 10
    • 1
    克隆类型
    • 49
    • 10
    多克隆
    标记
    • 27
    • 7
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ALOX15 antibody is conjugated to AbBy Fluor® 647
    应用范围
    • 33
    • 16
    • 16
    • 13
    • 12
    • 12
    • 12
    • 10
    • 4
    • 4
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    交叉反应
    人, 小鼠, 大鼠
    预测反应
    Cow,Pig
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human ALOX15/15 Lipoxygenase 1
    亚型
    IgG
    Top Product
    Discover our top product ALOX15 Primary Antibody
  • 应用备注
    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • Dalli, Colas, Arnardottir, Serhan: "Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution." in: Immunity, Vol. 46, Issue 1, pp. 92-105, (2017) (PubMed).

  • 抗原
    ALOX15 (Arachidonate 15-Lipoxygenase (ALOX15))
    别名
    15 Lipoxygenase 1 (ALOX15 产品)
    别名
    15-LOX-1 antibody, 15LOX-1 antibody, ALOX15 antibody, 12-LO antibody, Alox12l antibody, L-12LO antibody, 12-LOX antibody, Alox12 antibody, ALOX12 antibody, 15-LOX antibody, Alox12e antibody, arachidonate 15-lipoxygenase antibody, Arachidonate 15-lipoxygenase antibody, ALOX15 antibody, Alox15 antibody, Nmul_A0532 antibody, Sden_1680 antibody, Swoo_2919 antibody, PCC8801_3106 antibody, Cyan8802_3014 antibody, Nwat_1315 antibody
    背景

    Synonyms: 12-LOX, 15LOX-1, 15-LOX-1, Arachidonate 15-lipoxygenase, 15-LOX, 12/15-lipoxygenase, Arachidonate 12-lipoxygenase, leukocyte-type, Arachidonate omega-6 lipoxygenase, ALOX15, LOG15

    Background: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.

    基因ID
    246
    UniProt
    P16050
    途径
    Regulation of Actin Filament Polymerization
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