CD74 抗体 (C-Term)
-
- 抗原 See all CD74 抗体
- CD74 (HLA-DR-gamma (CD74))
-
抗原表位
- C-Term
-
适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This CD74 antibody is un-conjugated
-
应用范围
- Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- Recognizes human CD74, a type II transmembrane protein, which is also known as the MHC class II associated invariant chain. The Recognizes 33, 35 and 41 kD isoforms of CD74. The CD74 Molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74 is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, dendritic cells and by various types of carcinoma. Expression of CD74 is primarily intracellular with moderate expression at the cell surface of B cells and monocytes. The Bu45 antibody binds to an epitope within the extracytoplasmic domain of the CD74 Molecule, which is distal from the C-terminus. *Membrane permeabilization may enhance CD74 staining. XXX recommend the use of Leucoperm (product code BUF09) for this purpose.
- 纯化方法
- Protein G purified
- 免疫原
-
B lymphoblastoid cell line HFB1.
Type of Immunogen: Cells - 克隆位点
- BU45
- 亚型
- IgG1
- Top Product
- Discover our top product CD74 Primary Antibody
-
-
- 应用备注
-
Approved: Flo (1:25 - 1:50), IHC, IHC-Fr, IHC-P, IP
Usage: Flow Cytometry: Use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Method sheets are available on request. - 说明
-
Target Species of Antibody: Human
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- PBS, pH 7.4, 0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
- 抗原
- CD74 (HLA-DR-gamma (CD74))
- 别名
- CD74 / CLIP (CD74 产品)
- 别名
- DHLAG antibody, HLADG antibody, II antibody, Ia-GAMMA antibody, CLIP antibody, Ii antibody, INVG34 antibody, Iclp-1 antibody, iclp1 antibody, wu:fb11f09 antibody, wu:fb12a01 antibody, wu:fb13d06 antibody, wu:fk94e07 antibody, Iclp-2 antibody, cd74 antibody, iclp2 antibody, zgc:123161 antibody, CD74 molecule antibody, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) antibody, CD74 molecule, major histocompatibility complex, class II invariant chain a antibody, CD74 molecule, major histocompatibility complex, class II invariant chain b antibody, CD74 antibody, Cd74 antibody, cd74a antibody, cd74b antibody
- 背景
-
Name/Gene ID: CD74
Synonyms: CD74, CD74 antigen, DHLAG, HLADG, HLA-DR-gamma, Ia-associated invariant chain, p33, MHC HLA-DR gamma chain, Ia-GAMMA - 基因ID
- 972
- UniProt
- P04233
- 途径
- Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
-