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DAB1 抗体 (Tyr232)
DAB1
适用: 人, 小鼠, 大鼠
IHC (p)
宿主: 兔
Polyclonal
unconjugated
DAB1抗体详情
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抗原
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DAB1
(Disabled Homolog 1 (Drosophila) (DAB1))
抗原表位
All epitopes for DAB1 抗体
Tyr232
适用
All reactivities for DAB1 抗体
人, 小鼠, 大鼠
宿主
All hosts for DAB1 抗体
兔
克隆类型
All clonalities for DAB1 抗体
多克隆
标记
All conjugates for DAB1 抗体
This DAB1 antibody is un-conjugated
应用范围
All applications for DAB1 抗体
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
特异性
Dab1 antibody detects endogenous levels of total Dab1 protein.
纯化方法
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
免疫原
The antiserum was produced against synthesized non-phosphopeptide derived from human Dab1around the phosphorylation site of tyrosine 232 (G-V-YP-D-V).
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使用细节
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应用备注
Immunohistochemistry: 1: 50-1: 100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制
仅限研究用
贮存及处理
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浓度
1.0 mg/mL
缓冲液
PBS (without Mg2+ and Ca2+), pH 7.4 containing 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Avoid repeated freezing and thawing.
储存条件
-20 °C
DAB1目标详情
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抗原
DAB1
(Disabled Homolog 1 (Drosophila) (DAB1))
别名
DAB1 (DAB1 产品 )
别名
AI956902 antibody, C630028C02Rik antibody, scm antibody, scr antibody, scrambler antibody, yot antibody, disabled-1 antibody, LOC100232823 antibody, si:dkey-242m13.1 antibody, DAB1 antibody, zgc:136547 antibody, DAB1, reelin adaptor protein antibody, disabled 1 antibody, disabled homolog 1 antibody, Dab, reelin signal transducer, homolog 1a (Drosophila) antibody, Dab, reelin signal transducer, homolog 1b (Drosophila) antibody, DAB1 antibody, Dab1 antibody, LOC100232823 antibody, dab1a antibody, dab1b antibody
背景
Disruption of DAB 1 (Disable 1) results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. DAB1 acts downstream of reelin in a signalling pathway.Synonyms: Disabled homolog 1
基因ID
1600
NCBI登录号
NP_066566
UniProt
O75553
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