(3 references)-
- 抗原 See all ARHGEF1 抗体
- ARHGEF1 (rho Guanine Nucleotide Exchange Factor (GEF) 1 (ARHGEF1))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ARHGEF1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 亚型
- IgG
- Top Product
- Discover our top product ARHGEF1 Primary Antibody
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anti-rho Guanine Nucleotide Exchange Factor (GEF) 1 (ARHGEF1) (AA 830-927) antibody
ARHGEF1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4C4 unconjugated
anti-rho Guanine Nucleotide Exchange Factor (GEF) 1 (ARHGEF1) (AA 783-912) antibodyARHGEF1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-rho Guanine Nucleotide Exchange Factor (GEF) 1 (ARHGEF1) antibodyARHGEF1 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-rho Guanine Nucleotide Exchange Factor (GEF) 1 (ARHGEF1) (AA 830-927) antibodyARHGEF1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-rho Guanine Nucleotide Exchange Factor (GEF) 1 (ARHGEF1) (AA 1-912) antibodyARHGEF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-rho Guanine Nucleotide Exchange Factor (GEF) 1 (ARHGEF1) (AA 41-71), (N-Term) antibodyARHGEF1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-rho Guanine Nucleotide Exchange Factor (GEF) 1 (ARHGEF1) (N-Term) antibodyARHGEF1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-rho Guanine Nucleotide Exchange Factor (GEF) 1 (ARHGEF1) (AA 41-71) antibodyARHGEF1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
- 储存条件
- 4 °C,-20 °C
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: "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13." in: Science (New York, N.Y.), Vol. 280, Issue 5372, pp. 2112-4, (1998) (PubMed).
: "Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues." in: Oncogene, Vol. 14, Issue 14, pp. 1747-52, (1997) (PubMed).
: "Identification of a novel guanine nucleotide exchange factor for the Rho GTPase." in: The Journal of biological chemistry, Vol. 271, Issue 41, pp. 25452-8, (1996) (PubMed).
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: "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13." in: Science (New York, N.Y.), Vol. 280, Issue 5372, pp. 2112-4, (1998) (PubMed).
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- 抗原
- ARHGEF1 (rho Guanine Nucleotide Exchange Factor (GEF) 1 (ARHGEF1))
- 别名
- ARHGEF1 (ARHGEF1 产品)
- 别名
- arhgef1 antibody, cb473 antibody, zgc:158261 antibody, ARHGEF1 antibody, GEF1 antibody, LBCL2 antibody, LSC antibody, P115-RHOGEF antibody, SUB1.5 antibody, Lbcl2 antibody, Lsc antibody, Rho guanine nucleotide exchange factor (GEF) 1a antibody, Rho guanine nucleotide exchange factor 1 antibody, Rho guanine nucleotide exchange factor (GEF) 1 antibody, arhgef1a antibody, ARHGEF1 antibody, arhgef1 antibody, Arhgef1 antibody
- 背景
- Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation.
- 分子量
- 102435 Da
- 基因ID
- 9138
- UniProt
- Q92888
- 途径
- Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, Thromboxane A2 Receptor Signaling
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