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FEN1 抗体

FEN1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1944939
发货至: 中国
  • 抗原 See all FEN1 抗体
    FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))
    适用
    • 63
    • 43
    • 37
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    人, 小鼠, 大鼠
    宿主
    • 58
    • 9
    克隆类型
    • 56
    • 11
    多克隆
    标记
    • 43
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    This FEN1 antibody is un-conjugated
    应用范围
    • 55
    • 16
    • 15
    • 13
    • 13
    • 11
    • 9
    • 5
    • 1
    • 1
    • 1
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    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    亚型
    IgG
    Top Product
    Discover our top product FEN1 Primary Antibody
  • 应用备注
    IF: 1:100. WB: 1:1000. IHC: 1:50-1:100
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
    储存条件
    4 °C,-20 °C
  • Taylor, Noguchi, Totoki, Toyoda, Kuroki, Dewar, Lloyd, Itoh, Takeda, Kim, She, Barlow, Bloom, Bruford, Chang, Cuomo, Eichler, FitzGerald, Jaffe, LaButti, Nicol, Park, Seaman, Sougnez, Yang, Zimmer et al.: "Human chromosome 11 DNA sequence and analysis including novel gene identification. ..." in: Nature, Vol. 440, Issue 7083, pp. 497-500, (2006) (PubMed).

    Shen, Nolan, Sklar, Park: "Essential amino acids for substrate binding and catalysis of human flap endonuclease 1." in: The Journal of biological chemistry, Vol. 271, Issue 16, pp. 9173-6, (1996) (PubMed).

    Murray, Tavassoli, al-Harithy, Sheldrick, Lehmann, Carr, Watts: "Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage." in: Molecular and cellular biology, Vol. 14, Issue 7, pp. 4878-88, (1994) (PubMed).

    Robins, Pappin, Wood, Lindahl: "Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I." in: The Journal of biological chemistry, Vol. 269, Issue 46, pp. 28535-8, (1994) (PubMed).

  • 抗原
    FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))
    别名
    FEN1 (FEN1 产品)
    别名
    FEN-1 antibody, FEN1 antibody, AW538437 antibody, MF1 antibody, RAD2 antibody, cb879 antibody, fen-1 antibody, fen1 antibody, mf1 antibody, rad2 antibody, xFEN1a antibody, flap structure-specific endonuclease 1 antibody, flap endonuclease 1-like antibody, Flap endonuclease-1 antibody, 5'-3' exonuclease family protein antibody, flap structure specific endonuclease 1 antibody, flap structure-specific endonuclease 1 L homeolog antibody, nuclease, Rad2 family antibody, FEN1 antibody, LOC100808044 antibody, Bm1_49605 antibody, AT5G26680 antibody, Fen1 antibody, fen1 antibody, fen1.L antibody
    背景
    Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
    分子量
    42593 Da
    基因ID
    2237
    UniProt
    P39748
    途径
    Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA
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