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RAD23B 抗体 (N-Term)

Name: RAD23B 抗体 (N-Term)
SKU: ABIN1944896
Availability: OutOfStock

RAD23B 适用: 人, 小鼠, 大鼠 WB 宿主: 小鼠 Monoclonal 1228CT409-120-123-135 unconjugated

Western blot analysis of lysates from Jurkat, A549, HUVEC, mouse NIH/3T3 cell line and mouse brain, rat brain tissue lysates (from left to right), using RAD23B Antibody (N-term) (ABIN1944896 and ABIN2843646). (RAD23B 抗体 (N-Term))

1 image

(3 references)

产品编号 ABIN1944896

发货至: 中国

Datasheet as PDF

抗原 See all RAD23B 抗体

RAD23B (RAD23 Homolog B (RAD23B))
抗原表位
15

12

7

6

5

5

4

4

2

1

1

1

1

1

1

1

1

1

1

1

1
AA 1-409, N-Term
适用
89

35

34

6

5

4

4

4

4

3

3

2

2

1
人, 小鼠, 大鼠
宿主
71

17

1
小鼠
Compatible Secondaries
克隆类型
71

18
单克隆
标记
49

5

4

4

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This RAD23B antibody is un-conjugated
应用范围
69

29

25

17

15

14

13

10

8

3

3

2

2

2

1

1

1

1
Western Blotting (WB)

纯化方法

This antibody is purified through a protein G column, followed by dialysis against PBS.

免疫原

This RAD23B antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 1-409 amino acids from the N-terminal region of human RAD23B.

克隆位点

1228CT409-120-123-135

亚型

IgG1 kappa

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anti-RAD23 Homolog B (RAD23B) antibody
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anti-RAD23 Homolog B (RAD23B) (AA 1-409) antibody
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anti-RAD23 Homolog B (RAD23B) (AA 164-409) antibody
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anti-RAD23 Homolog B (RAD23B) (Center) antibody
RAD23B 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-RAD23 Homolog B (RAD23B) (AA 163-176) antibody
RAD23B 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-RAD23 Homolog B (RAD23B) (AA 24-120) antibody
RAD23B 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (p), IF (cc), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-RAD23 Homolog B (RAD23B) (N-Term) antibody
RAD23B 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000

限制

仅限研究用
状态

Liquid

缓冲液

Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Huang, Wang, Xu, Lu, Xu, Li, Zhou, Sha: "Expression of a novel RAD23B mRNA splice variant in the human testis." in: Journal of andrology, Vol. 25, Issue 3, pp. 363-8, (2004) (PubMed).

Humphray, Oliver, Hunt, Plumb, Loveland, Howe, Andrews, Searle, Hunt, Scott, Jones, Ainscough, Almeida, Ambrose, Ashwell, Babbage, Babbage, Bagguley, Bailey, Banerjee, Barker, Barlow, Bates, Beasley et al.: "DNA sequence and analysis of human chromosome 9. ..." in: Nature, Vol. 429, Issue 6990, pp. 369-74, (2004) (PubMed).

Masutani, Sugasawa, Yanagisawa, Sonoyama, Ui, Enomoto, Takio, Tanaka, van der Spek, Bootsma: "Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23." in: The EMBO journal, Vol. 13, Issue 8, pp. 1831-43, (1994) (PubMed).
抗原

RAD23B (RAD23 Homolog B (RAD23B))

别名

RAD23B (RAD23B 产品)

别名

HHR23B antibody, HR23B antibody, P58 antibody, 0610007D13Rik antibody, AV001138 antibody, mHR23B antibody, p58 antibody, MGC107846 antibody, zgc:65951 antibody, RAD23 homolog B, nucleotide excision repair protein antibody, UV excision repair protein RAD23 homolog B antibody, RAD23 homolog B, nucleotide excision repair protein S homeolog antibody, RAD23B antibody, Rad23b antibody, rd23b antibody, rad23b antibody, rad23b.S antibody

背景

Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum- associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER, it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1.

分子量

43171

基因ID

5887

UniProt

P54727

途径

DNA Damage Repair