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CCL20 抗体

CCL20 适用: 人 IP, IHC (p), FACS, IHC (fro) 宿主: 小鼠 Monoclonal UCHL1 unconjugated
产品编号 ABIN192395
发货至: 中国
  • 抗原 See all CCL20 抗体
    CCL20 (Chemokine (C-C Motif) Ligand 20 (CCL20))
    适用
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    宿主
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    小鼠
    克隆类型
    • 58
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    单克隆
    标记
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    This CCL20 antibody is un-conjugated
    应用范围
    • 49
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    Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    The antibody UCHL1 recognizes an extracellular epitope of CD45R0, a 180 kDa low molecular weight isoform of the leukocyte common antigen (LCA). The antigen is expressed on a subset of memory/activated T cells and on cortical thymocytes.
    交叉反应 (详细)
    Human
    纯化方法
    Purified by protein-A affinity chromatography.
    纯度
    > 95 % (by SDS-PAGE)
    免疫原
    Human IL-2 dependent T cells
    克隆位点
    UCHL1
    亚型
    IgG2a
    Top Product
    Discover our top product CCL20 Primary Antibody
  • 应用备注
    Immunohistochemistry (paraffin sections): This product does not require protein digestion pretreatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Positive tissue: tonsil.
    Immunohistochemistry (frozen sections): Positive tissue: tonsil.
    Flow cytometry: Recommended dilution: 10 μg/mL.
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Do not freeze.
  • Akbar, Terry, Timms, Beverley, Janossy: "Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 140, Issue 7, pp. 2171-8, (1988) (PubMed).

    Beverley, Merkenschlager, Terry: "Phenotypic diversity of the CD45 antigen and its relationship to function." in: Immunology. Supplement, Vol. 1, pp. 3-5, (1988) (PubMed).

    Terry, Brown, Beverley: "The monoclonal antibody, UCHL1, recognizes a 180,000 MW component of the human leucocyte-common antigen, CD45." in: Immunology, Vol. 64, Issue 2, pp. 331-6, (1988) (PubMed).

    Beverley: "Human T cell subsets." in: Immunology letters, Vol. 14, Issue 4, pp. 263-7, (1987) (PubMed).

    Norton, Ramsay, Smith, Beverley, Isaacson: "Monoclonal antibody (UCHL1) that recognises normal and neoplastic T cells in routinely fixed tissues." in: Journal of clinical pathology, Vol. 39, Issue 4, pp. 399-405, (1986) (PubMed).

    Smith, Brown, Rowe, Callard, Beverley: "Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1." in: Immunology, Vol. 58, Issue 1, pp. 63-70, (1986) (PubMed).

  • 抗原
    CCL20 (Chemokine (C-C Motif) Ligand 20 (CCL20))
    别名
    CD45R0 (CCL20 产品)
    别名
    MIP-3ALPHA antibody, CCL20 antibody, si:dkey-150o13.1 antibody, CKb4 antibody, LARC antibody, MIP-3-alpha antibody, MIP-3a antibody, MIP3A antibody, SCYA20 antibody, ST38 antibody, MIP-3A antibody, MIP-3[a] antibody, Scya20 antibody, exodus-1 antibody, C-C motif chemokine ligand 20 antibody, chemokine (C-C motif) ligand 20b antibody, chemokine (C-C motif) ligand 20 antibody, CCL20 antibody, ccl20b antibody, Ccl20 antibody
    背景
    CD45R0 is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45R0 is expressed e.g. on macrophages, CD8+ T cells, activated T cells and myeloma cells.,PTPRCR, T200R0
    途径
    The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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