Immunoblotting: Use at 1-5 μg/mL. A band of ~50-60 kDa is detected. Immunohistochemistry: use at 1-10 μg/mL. These are recommended concentrations. Endusers should determine optimal concentrations for their applications.
限制
仅限研究用
状态
Liquid
溶解方式
Dilute in PBS or medium that is identical to that used in the assay system.
浓度
Lot specific
缓冲液
PBS, 50 % glycerol, 0.09 % sodium azide
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
储存方法
This antibody is stable for at least one (1) year at -20°C.
抗原
CAMK2A
(Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A))
camk2 antibody, camk2b antibody, zgc:112538 antibody, zgc:123320 antibody, CAMKA antibody, CaMKII antibody, R74975 antibody, mKIAA0968 antibody, PK2CDD antibody, PKCCD antibody, calcium/calmodulin dependent protein kinase II alpha antibody, calcium/calmodulin dependent protein kinase (CaM kinase) II alpha S homeolog antibody, calcium/calmodulin-dependent protein kinase II alpha antibody, CAMK2A antibody, camk2a.S antibody, camk2a antibody, Camk2a antibody
背景
Calcium/calmodulin-dependent protein kinase type II subunit α,Calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine-specific protein kinase that is regulated by the Ca2+/calmodulin complex. CaMKII is involved in many signaling cascades and is thought to be an important mediator of learning and memory. CaMKII is also necessary for Ca2+ homeostasis and reuptake in cardiomyocytes, chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. CaMKII has 28 different isoforms that derive from the alpha, beta, gamma, and delta genes. Misregulation of CaMKII is linked to Alzheimer's disease, Angelman syndrome, and heart arrhythmia.,CaM kinase II subunit α, CaMK-II subunit α, EC 2.7.11.17