tara antibody, DFNB28 antibody, TARA antibody, dJ37E16.4 antibody, AI428493 antibody, EST478828 antibody, Tara antibody, mKIAA1662 antibody, TRIO and F-actin binding protein antibody, TRIO and F-actin-binding protein antibody, TRIO and F-actin binding protein L homeolog antibody, TRIO and F-actin binding protein-like antibody, TRIOBP antibody, LOC100354753 antibody, triobp.L antibody, TRIOBPL antibody, Triobp antibody
背景
This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region.The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth.The protein also associates with F-actin and stabilizes F-actin structures.Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness.Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD).[provided by RefSeq]