HLA-DR Beta 抗体 (AA 1-262)
HLA-DRB
适用: 人
WB
宿主: 兔
Polyclonal
unconjugated
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- 抗原 See all HLA-DR Beta (HLA-DRB) products
- HLA-DR Beta (HLA-DRB) (Major Histocompatibility Complex, Class II, DR beta (HLA-DRB))
- 抗原表位
- AA 1-262
- 适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HLA-DR Beta antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- Purified by antigen-affinity chromatography.
- 免疫原
- Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 262 of Human HLA-DRB4
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- 应用备注
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Suggested dilutions:
Western blotting: 1.500-1.3000 - 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.
- 储存液
- Thimerosal (Merthiolate)
- 注意事项
- Biohazard Informations: This product contains thimerosal which is hazardous.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- 抗原
- HLA-DR Beta (HLA-DRB) (Major Histocompatibility Complex, Class II, DR beta (HLA-DRB))
- Abstract
- HLA-DRB 产品
- 背景
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HLA-DRB4 belongs to the HLA class II beta chain paralogues.This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane.It plays a central role in the immune system by presenting peptides derived from extracellular proteins.Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).The beta chain is approximately 26-28 kDa and its gene contains 6 exons.Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities.Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5.The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted.There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.[provided by RefSeq]
- 分子量
- 30 kDa
- 基因ID
- 3126
- NCBI登录号
- NM_021983, NP_068818
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