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UCHL1 抗体

UCHL1 适用: 人, 大鼠 WB, IHC (p) 宿主: 小鼠 Monoclonal 696CT2-1-4 unconjugated
产品编号 ABIN1882287
发货至: 中国
  • 抗原 See all UCHL1 抗体
    UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))
    适用
    • 176
    • 98
    • 92
    • 43
    • 31
    • 17
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    • 4
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    人, 大鼠
    宿主
    • 101
    • 74
    • 4
    • 3
    • 3
    • 2
    小鼠
    克隆类型
    • 99
    • 87
    单克隆
    标记
    • 111
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    • 1
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    • 1
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    • 1
    • 1
    • 1
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    This UCHL1 antibody is un-conjugated
    应用范围
    • 149
    • 60
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    • 38
    • 26
    • 26
    • 14
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    • 13
    • 11
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    预测反应
    B, Hs, Pr, M, Pig
    纯化方法
    This antibody is purified through a protein G column, followed by dialysis against PBS.
    免疫原
    This UCHL1 Monoclonal antibody is generated from mouses immunized with a KLH conjugated synthetic peptide selected from the 185-214 region of human UCHL1.
    克隆位点
    696CT2-1-4
    亚型
    IgG1
    Top Product
    Discover our top product UCHL1 Primary Antibody
  • 应用备注
    WB: 1:1000. IHC-P: 1:25. IHC-P: 1:25
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • Boudreaux, Maiti, Davies, Das: "Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 20, pp. 9117-22, (2010) (PubMed).

    Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." in: Nature, Vol. 434, Issue 7034, pp. 724-31, (2005) (PubMed).

    Choi, Levey, Weintraub, Rees, Gearing, Chin, Li: "Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases." in: The Journal of biological chemistry, Vol. 279, Issue 13, pp. 13256-64, (2004) (PubMed).

    Day, Hinks, Thompson: "The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase." in: The Biochemical journal, Vol. 268, Issue 2, pp. 521-4, (1990) (PubMed).

  • 抗原
    UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))
    别名
    UCHL1 (UCHL1 产品)
    背景
    Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
    分子量
    24824
    NCBI登录号
    NP_004172
    UniProt
    P09936
    途径
    Feeding Behaviour
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