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ERK2 抗体 (C-Term)

Name: ERK2 抗体 (C-Term)
SKU: ABIN1882175
Availability: OutOfStock

MAPK1 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB11608 unconjugated

PK1 Antibody (C-term) (ABIN1882175 and ABIN2841383) western blot analysis in Hela cell line lysates (35 μg/lane). (ERK2 抗体 (C-Term))

PK1 Antibody (C-term) (ABIN1882175 and ABIN2841383) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram). (ERK2 抗体 (C-Term))

FACS

Forlin-fixed and paraffin-embedded hun breast carcino tissue reacted with PK1 Antibody (C-term) (ABIN1882175 and ABIN2841383) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (ERK2 抗体 (C-Term))

IHC (p)

3 images

(5 references)

产品编号 ABIN1882175

发货至: 中国

Datasheet as PDF

抗原 See all ERK2 (MAPK1) 抗体

ERK2 (MAPK1) (Mitogen-Activated Protein Kinase 1 (MAPK1))
抗原表位
11

8

8

7

6

5

5

4

4

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1
AA 316-345, C-Term
适用
113

56

54

13

8

6

6

6

4

4

4

3

3

2

2
人
宿主
82

30

4

3

1
兔
Compatible Secondaries
克隆类型
78

43
多克隆
标记
81

9

6

3

2

2

2

2

2

2

2

2

2

2

1

1
This ERK2 antibody is un-conjugated
应用范围
88

55

43

26

24

20

8

8

6

2

1

1

1

1

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

预测反应

B, M, Rat

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This MAPK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 316-345 amino acids from the C-terminal region of human MAPK1.

克隆位点

RB11608

亚型

Ig Fraction

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anti-Mitogen-Activated Protein Kinase 1 (MAPK1) (AA 261-360) antibody
MAPK1 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 1D1 unconjugated

anti-Mitogen-Activated Protein Kinase 1 (MAPK1) antibody
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anti-Mitogen-Activated Protein Kinase 1 (MAPK1) antibody
MAPK1 适用: 人, 大鼠, 犬, 猴 WB, IHC, IF, IP, IHC (p) 宿主: 小鼠 Monoclonal 4C2 unconjugated

anti-Mitogen-Activated Protein Kinase 1 (MAPK1) antibody
MAPK1 适用: 人 WB, IHC, IP, IHC (p) 宿主: 小鼠 Monoclonal 9E9 unconjugated

anti-Mitogen-Activated Protein Kinase 1 (MAPK1) antibody
MAPK1 适用: 人, 大鼠, 犬, 猴 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 9H1 unconjugated

anti-Mitogen-Activated Protein Kinase 1 (MAPK1) (AA 200-300) antibody
MAPK1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 1 (MAPK1) (N-Term) antibody
MAPK1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 1 (MAPK1) (AA 310-360) antibody
MAPK1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Munshi, Wu, Mukhopadhyay, Ottaviano, Sassano, Koblinski, Platanias, Stack et al.: "Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth ..." in: The Journal of biological chemistry, Vol. 279, Issue 37, pp. 39042-50, (2004) (PubMed).

Mukherjee, Huang, Petkova, Albanese, Pestell, Braunstein, Christ, Wittner, Lisanti, Berman, Weiss, Tanowitz: "Trypanosoma cruzi infection activates extracellular signal-regulated kinase in cultured endothelial and smooth muscle cells." in: Infection and immunity, Vol. 72, Issue 9, pp. 5274-82, (2004) (PubMed).

Lou, Xie, Zhang, Yao, Luo, Wang, Shi, Yao: "Nek2A specifies the centrosomal localization of Erk2." in: Biochemical and biophysical research communications, Vol. 321, Issue 2, pp. 495-501, (2004) (PubMed).

Mitsushima, Suwa, Amachi, Ueda, Kioka: "Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin." in: The Journal of biological chemistry, Vol. 279, Issue 33, pp. 34570-7, (2004) (PubMed).

Huang, Chang, Liu: "Basic fibroblast growth factor antagonizes activin A-mediated growth inhibition and hemoglobin synthesis in K562 cells by activating ERK1/2 and deactivating p38 MAP kinase." in: Biochemical and biophysical research communications, Vol. 320, Issue 4, pp. 1247-52, (2004) (PubMed).
抗原

ERK2 (MAPK1) (Mitogen-Activated Protein Kinase 1 (MAPK1))

别名

MAPK1 (MAPK1 产品)

背景

MAPK1 is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets.

分子量

41390

NCBI登录号

NP_002736, NP_620407

UniProt

P28482

途径

MAPK Pathway, RTK signaling, Apoptosis, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process, Autophagy, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, BCR Signaling, S100 Proteins