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TYMS 抗体 (C-Term)

Name: TYMS 抗体 (C-Term)
SKU: ABIN1882144
Availability: OutOfStock

TYMS 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB20041 unconjugated

Western blot analysis of lysate from Jurkat cell line, using TYSY Antibody (C-term) (ABIN1882144 and ABIN2840937). (TYMS 抗体 (C-Term))

Flow cytometric analysis of WiDr cells using TYSY Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). (TYMS 抗体 (C-Term))

FACS

Confocal immunofluorescent analysis of TYSY Antibody (C-term) (ABIN1882144 and ABIN2840937) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (TYMS 抗体 (C-Term))

Formalin-fixed and paraffin-embedded human colon carcinoma with TYSY Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (TYMS 抗体 (C-Term))

IHC (p)

4 images

(3 references)

产品编号 ABIN1882144

发货至: 中国

Datasheet as PDF

抗原 See all TYMS 抗体

TYMS (Thymidylate Synthetase (TYMS))
抗原表位
15

12

6

5

3

3

3

1

1

1

1

1
AA 265-294, C-Term
适用
97

29

14

3

2

2

2

1

1

1
人
宿主
54

42

1
兔
Compatible Secondaries
克隆类型
49

48
多克隆
标记
45

7

4

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This TYMS antibody is un-conjugated
应用范围
50

41

33

22

19

19

18

16

14

13

9

7

6

3

3

2

2

1

1
Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This TYSY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the C-terminal region of human TYSY.

克隆位点

RB20041

亚型

Ig Fraction

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anti-Thymidylate Synthetase (TYMS) (AA 111-210) antibody
TYMS 适用: 人 WB, IF, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3A1 unconjugated

anti-Thymidylate Synthetase (TYMS) (AA 60-174) antibody
TYMS 适用: 人 WB, IF, FACS, IHC, ISt, RIA, StM 宿主: 小鼠 Monoclonal TYMS-1884 unconjugated

anti-Thymidylate Synthetase (TYMS) antibody
TYMS 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1D6 unconjugated

anti-Thymidylate Synthetase (TYMS) antibody
TYMS 适用: 人 WB, IF, IHC (p), IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Thymidylate Synthetase (TYMS) antibody
TYMS 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5H8 unconjugated

anti-Thymidylate Synthetase (TYMS) (AA 111-210) antibody
TYMS 适用: 人 WB, ELISA, IHC (p), IP 宿主: 小鼠 Monoclonal 2B2 unconjugated

anti-Thymidylate Synthetase (TYMS) (AA 2-54) antibody
TYMS 适用: 人 WB, IF, ELISA, IP 宿主: 兔 Polyclonal unconjugated

anti-Thymidylate Synthetase (TYMS) antibody
TYMS 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated

anti-Thymidylate Synthetase (TYMS) (AA 60-174) antibody
TYMS 适用: 人 IF, FACS, ELISA, RIA, Coat 宿主: 小鼠 Monoclonal rTYMS-1884 unconjugated Recombinant Antibody

应用备注

IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Ma, He, Zhang, Fei, Niu, Wang, Ding, Xu, Chen, Zhu: "DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression." in: The Journal of biological chemistry, Vol. 287, Issue 8, pp. 5639-49, (2012) (PubMed).

Ren, Kim, Koh, Chang, Eom, Yi, Seong, Kim, Bronner, Cho: "Comparative analysis of thymidylate synthase at the protein, mRNA, and DNA levels as prognostic markers in colorectal adenocarcinoma." in: Journal of surgical oncology, Vol. 100, Issue 7, pp. 546-52, (2009) (PubMed).

Schiffer, Clifton, Davisson, Santi, Stroud: "Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site." in: Biochemistry, Vol. 34, Issue 50, pp. 16279-87, (1996) (PubMed).
抗原

TYMS (Thymidylate Synthetase (TYMS))

Abstract

TYMS 产品

别名

FN1 antibody, ECK2823 antibody, JW2795 antibody, ts antibody, Ts antibody, HST422 antibody, TMS antibody, TS antibody, thymidylate synthetase antibody, contains intron in T4 phage antibody, ThyE antibody, thymidylate synthase antibody, thymidylate synthetase L homeolog antibody, TYMS antibody, thyA antibody, td antibody, thyE antibody, DDA3937_RS04960 antibody, tyms.L antibody, XBJ1_RS15770 antibody, EAMY_RS20680 antibody, Tyms antibody

背景

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.

分子量

35716

NCBI登录号

NP_001062

UniProt

P04818

途径

Mitotic G1-G1/S Phases