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TOLLIP 抗体 (C-Term)

Name: TOLLIP 抗体 (C-Term)
SKU: ABIN1882142
Availability: OutOfStock

TOLLIP 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4409 unconjugated

Western blot analysis of TOLLIP (arrow) using rabbit polyclonal TOLLIP Antibody (ABIN1882142 and ABIN2839205). (TOLLIP 抗体 (C-Term))

Middle panels, TOLLIP expression in matched normal and tumor breast samples. (TOLLIP 抗体 (C-Term))

IHC (p)

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (TOLLIP 抗体 (C-Term))

IHC (p)

3 images

(5 references)

产品编号 ABIN1882142

发货至: 中国

Datasheet as PDF

抗原 See all TOLLIP 抗体

TOLLIP (Toll Interacting Protein (TOLLIP))
抗原表位
15

7

5

3

3

3

2

2

2

1

1

1

1
AA 221-250, C-Term
适用
41

30

20

17

5

4

3

3

3

3

2

1

1

1
人
宿主
46

11

1
兔
Compatible Secondaries
克隆类型
49

10
多克隆
标记
34

3

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This TOLLIP antibody is un-conjugated
应用范围
31

18

13

13

13

8

8

7

5

3

2

2

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This TOLLIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-250 amino acids from the C-terminal region of human TOLLIP.

克隆位点

RB4409

亚型

Ig Fraction

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anti-Toll Interacting Protein (TOLLIP) (AA 1-274) antibody
TOLLIP 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Toll Interacting Protein (TOLLIP) (AA 1-274) antibody
TOLLIP 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1A5-2A3 unconjugated

anti-Toll Interacting Protein (TOLLIP) (AA 19-254) antibody
TOLLIP 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Toll Interacting Protein (TOLLIP) (AA 1-274) antibody
TOLLIP 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Toll Interacting Protein (TOLLIP) (AA 1-274) antibody
TOLLIP 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

anti-Toll Interacting Protein (TOLLIP) (AA 28-261) antibody
TOLLIP 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated

anti-Toll Interacting Protein (TOLLIP) (AA 86-163) antibody
TOLLIP 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Toll Interacting Protein (TOLLIP) (AA 1-274) antibody
TOLLIP 适用: 小鼠 WB, IP, ICC 宿主: 小鼠 Monoclonal Kimmy-2 unconjugated

anti-Toll Interacting Protein (TOLLIP) antibody
TOLLIP 适用: 人, 小鼠 WB, IP 宿主: 大鼠 Monoclonal Kimmy-1 unconjugated

anti-Toll Interacting Protein (TOLLIP) (N-Term) antibody
TOLLIP 适用: 人, 小鼠, 大鼠, 斑马鱼, 猴, 马, 兔, 豚鼠, 犬, Hamster WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Chen, Choong, Lin, Philp, Wong, Ang, Tan, Loh, Hew, Shah, Druker, Chong, Lim: "Differential expression of novel tyrosine kinase substrates during breast cancer development." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 12, pp. 2072-87, (2007) (PubMed).

Zhang, Ghosh: "Negative regulation of toll-like receptor-mediated signaling by Tollip." in: The Journal of biological chemistry, Vol. 277, Issue 9, pp. 7059-65, (2002) (PubMed).

Bulut, Faure, Thomas, Equils, Arditi et al.: "Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 2, pp. 987-94, (2001) (PubMed).

Burns, Clatworthy, Martin, Martinon, Plumpton, Maschera, Lewis, Ray, Tschopp, Volpe: "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor." in: Nature cell biology, Vol. 2, Issue 6, pp. 346-51, (2000) (PubMed).

Volpe, Clatworthy, Kaptein, Maschera, Griffin, Ray: "The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex." in: FEBS letters, Vol. 419, Issue 1, pp. 41-4, (1998) (PubMed).
抗原

TOLLIP (Toll Interacting Protein (TOLLIP))

别名

TOLLIP (TOLLIP 产品)

别名

IL-1RAcPIP antibody, 4930403G24Rik antibody, 4931428G15Rik antibody, fk22a02 antibody, im:7145391 antibody, wu:fk22a02 antibody, zgc:76985 antibody, TOLLIP antibody, GB17961 antibody, tollip antibody, tollip1 antibody, tollipa antibody, TOLIP antibody, toll interacting protein antibody, toll-interacting protein antibody, toll-interacting protein-like antibody, toll interacting protein L homeolog antibody, toll interacting protein S homeolog antibody, Toll-interleukine I receptor interacting protein I antibody, TOLLIP antibody, Tollip antibody, tollip antibody, LOC552034 antibody, LOC100169858 antibody, tollip.L antibody, tollip.S antibody, LOC100136122 antibody

背景

Toll like protein is a component of the signaling pathway of IL1 and Toll like receptors. It inhibits cell activation by microbial products. Tollip recruits IRAK1 to the IL1 receptor complex and inhibits IRAK1 phosphorylation and kinase activity. It oligomerizes and binds to TLR2 and the TLR4-MD2 complex via its C terminus. It exists as a complex with IRAK1 in unstimulated cells. Upon IL1 signaling, Tollip binds to the activated IL1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. TOLLIP also interacts with TLR2 and TLR4, TOLLIP overexpression inhibits nuclear factor kappa-B (NFKB) activation in response to lipopolysaccharide and IL1B.

分子量

30282

NCBI登录号

NP_061882

UniProt

Q9H0E2