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- 抗原 See all TK2 抗体
- TK2 (Thymidine Kinase 2, Mitochondrial (TK2))
- 抗原表位
- AA 8-38, N-Term
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆类型
- 多克隆
- 应用范围
- Western Blotting (WB)
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- 免疫原
- This Thymidine Kinase 2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-38 amino acids from the N-terminal region of human Thymidine Kinase 2.
- 克隆位点
- RB5434
- 亚型
- Ig Fraction
-
- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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- 抗原
- TK2 (Thymidine Kinase 2, Mitochondrial (TK2))
- Abstract
- TK2 产品
- 别名
- MTDPS2 antibody, MTTK antibody, AU024611 antibody, mt-TK antibody, tk2 antibody, zgc:100948 antibody, thymidine kinase 2, mitochondrial antibody, thymidine kinase 2, mitochondrial S homeolog antibody, TK2 antibody, Tk2 antibody, tk2.S antibody, tk2 antibody
- 背景
- Thymidine kinase-2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, and also phosphorylates antiviral and anticancer nucleoside analogs. Both recombinant and native forms of the enzyme have broad substrate specificity and complex kinetics, suggesting that it may play a role in the activation of chemotherapeutic nucleoside analogs. The highest levels of expression are observed in testis and ovary. The main supply of deoxyribonucleotides (dNTPs) for mitochondrial DNA synthesis comes from the salvage pathway initiated by deoxyguanosine kinase (DGK) and TK2. The association of mitochondrial DNA depletion with mutations in the genes encoding these 2 kinases suggests that the salvage pathway enzymes are involved in the maintenance of balanced mitochondrial dNTP pools.
- 分子量
- 31005
- NCBI登录号
- NP_001166114, NP_001166115, NP_001258864, NP_004605
- UniProt
- O00142
- 途径
- Mitotic G1-G1/S Phases
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