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TK2 抗体 (N-Term)

TK2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB5434 unconjugated
产品编号 ABIN1882141
发货至: 中国
  • 抗原 See all TK2 抗体
    TK2 (Thymidine Kinase 2, Mitochondrial (TK2))
    抗原表位
    AA 8-38, N-Term
    适用
    人, 小鼠
    宿主
    克隆类型
    多克隆
    应用范围
    Western Blotting (WB)
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This Thymidine Kinase 2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-38 amino acids from the N-terminal region of human Thymidine Kinase 2.
    克隆位点
    RB5434
    亚型
    Ig Fraction
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • 抗原
    TK2 (Thymidine Kinase 2, Mitochondrial (TK2))
    Abstract
    TK2 产品
    别名
    MTDPS2 antibody, MTTK antibody, AU024611 antibody, mt-TK antibody, tk2 antibody, zgc:100948 antibody, thymidine kinase 2, mitochondrial antibody, thymidine kinase 2, mitochondrial S homeolog antibody, TK2 antibody, Tk2 antibody, tk2.S antibody, tk2 antibody
    背景
    Thymidine kinase-2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, and also phosphorylates antiviral and anticancer nucleoside analogs. Both recombinant and native forms of the enzyme have broad substrate specificity and complex kinetics, suggesting that it may play a role in the activation of chemotherapeutic nucleoside analogs. The highest levels of expression are observed in testis and ovary. The main supply of deoxyribonucleotides (dNTPs) for mitochondrial DNA synthesis comes from the salvage pathway initiated by deoxyguanosine kinase (DGK) and TK2. The association of mitochondrial DNA depletion with mutations in the genes encoding these 2 kinases suggests that the salvage pathway enzymes are involved in the maintenance of balanced mitochondrial dNTP pools.
    分子量
    31005
    NCBI登录号
    NP_001166114, NP_001166115, NP_001258864, NP_004605
    UniProt
    O00142
    途径
    Mitotic G1-G1/S Phases
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