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- 抗原 See all SYVN1 抗体
- SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))
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抗原表位
- AA 58-88, N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SYVN1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 预测反应
- M, X
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- 免疫原
- This SYVN1 (HRD1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-88 amino acids from the N-terminal region of human SYVN1 (HRD1).
- 克隆位点
- RB5086
- 亚型
- Ig Fraction
- Top Product
- Discover our top product SYVN1 Primary Antibody
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- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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Activating transcription factor 6 limits intracellular accumulation of mutant ?(1)-antitrypsin Z and mitochondrial damage in hepatoma cells." in: The Journal of biological chemistry, Vol. 286, Issue 48, pp. 41563-77, (2011) (PubMed).
: "Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control." in: The Journal of biological chemistry, Vol. 286, Issue 43, pp. 37602-14, (2011) (PubMed).
: "Cutting Edge: Selective role of ubiquitin in MHC class I antigen presentation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 4, pp. 1904-8, (2011) (PubMed).
: "Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum." in: The Journal of biological chemistry, Vol. 279, Issue 5, pp. 3525-34, (2004) (PubMed).
: "Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy." in: Genes & development, Vol. 17, Issue 19, pp. 2436-49, (2003) (PubMed).
: "A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1." in: Biochemical and biophysical research communications, Vol. 303, Issue 1, pp. 91-7, (2003) (PubMed).
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Activating transcription factor 6 limits intracellular accumulation of mutant ?(1)-antitrypsin Z and mitochondrial damage in hepatoma cells." in: The Journal of biological chemistry, Vol. 286, Issue 48, pp. 41563-77, (2011) (PubMed).
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- 抗原
- SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))
- 别名
- SYVN1 (HRD1) (SYVN1 产品)
- 别名
- DER3 antibody, HRD1 antibody, hrd1 antibody, 1200010C09Rik antibody, AW211966 antibody, C85322 antibody, D530017H19Rik antibody, Hrd1 antibody, RGD1310488 antibody, syvn1 antibody, syvn1-a antibody, syvn1-b antibody, wu:fk91f10 antibody, zgc:55735 antibody, zgc:77108 antibody, synoviolin 1 antibody, synovial apoptosis inhibitor 1, synoviolin antibody, synoviolin 1 S homeolog antibody, SYVN1 antibody, syvn1 antibody, Syvn1 antibody, syvn1.S antibody
- 背景
- HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Synoviolin/Hrd1 (expressed in rheumatoid synovium) is reported to be a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects. HRD1 contains one ring-type zinc finger.
- 分子量
- 67685
- NCBI登录号
- NP_115807, NP_757385
- UniProt
- Q86TM6
- 途径
- ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling
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