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MTM1 抗体 (N-Term)

Name: MTM1 抗体 (N-Term)
SKU: ABIN1882103
Availability: OutOfStock

MTM1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB0722 unconjugated

Western blot analysis of anti-MTM1 Antibody (N-term) (ABIN1882103 and ABIN2841036) in HL60 cell line lysates (35 μg/lane). (MTM1 抗体 (N-Term))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (MTM1 抗体 (N-Term))

IHC (p)

2 images

(6 references)

产品编号 ABIN1882103

发货至: 中国

Datasheet as PDF

抗原 See all MTM1 抗体

MTM1 (Myotubularin 1 (MTM1))
抗原表位
16

8

4

2

2

2

1

1

1

1

1
AA 1-30, N-Term
适用
43

38

25

2

2

2

2

1

1

1
人
宿主
41

3

1
兔
Compatible Secondaries
克隆类型
43

2
多克隆
标记
19

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This MTM1 antibody is un-conjugated
应用范围
39

15

14

13

5

4

1

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

预测反应

B

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This MTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MTM1.

克隆位点

RB0722

亚型

Ig Fraction

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anti-Myotubularin 1 (MTM1) (C-Term) antibody
Verified MTM1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated

anti-Myotubularin 1 (MTM1) (AA 1-603) antibody
MTM1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Myotubularin 1 (MTM1) (AA 225-275) antibody
MTM1 适用: 人, 小鼠, 大鼠 WB, FACS, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Myotubularin 1 (MTM1) (AA 484-603) antibody
MTM1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Myotubularin 1 (MTM1) (AA 1-603) antibody
MTM1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

anti-Myotubularin 1 (MTM1) (C-Term) antibody
MTM1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Myotubularin 1 (MTM1) (AA 566-594), (C-Term) antibody
MTM1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB0856 unconjugated

anti-Myotubularin 1 (MTM1) (AA 451-485) antibody
MTM1 适用: 斑马鱼 WB 宿主: 兔 Polyclonal RB52010 unconjugated

anti-Myotubularin 1 (MTM1) (Internal Region) antibody
MTM1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Jian, Cheng, Jiang, Deng, Hu, Zhang: "A cDNA-based random RNA interference library for functional genetic screens in embryonic stem cells." in: Stem cells (Dayton, Ohio), Vol. 25, Issue 8, pp. 1904-12, (2007) (PubMed).

Nandurkar, Layton, Laporte, Selan, Corcoran, Caldwell, Mochizuki, Majerus, Mitchell: "Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 15, pp. 8660-5, (2003) (PubMed).

Biancalana, Caron, Gallati, Baas, Kress, Novelli, DApice, Lagier-Tourenne, Buj-Bello, Romero, Mandel: "Characterisation of mutations in 77 patients with X-linked myotubular myopathy, including a family with a very mild phenotype." in: Human genetics, Vol. 112, Issue 2, pp. 135-42, (2003) (PubMed).

Herman, Kopacz, Zhao, Mills, Metzenberg, Das: "Characterization of mutations in fifty North American patients with X-linked myotubular myopathy." in: Human mutation, Vol. 19, Issue 2, pp. 114-21, (2002) (PubMed).

Wishart, Dixon: "PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease." in: Trends in cell biology, Vol. 12, Issue 12, pp. 579-85, (2002) (PubMed).

Sutton, Winer, Norman, Liechti-Gallati, MacDonald: "Limb girdle and facial weakness in female carriers of X-linked myotubular myopathy mutations." in: Neurology, Vol. 57, Issue 5, pp. 900-2, (2001) (PubMed).
抗原

MTM1 (Myotubularin 1 (MTM1))

别名

MTM1 (MTM1 产品)

别名

CNM antibody, MTMX antibody, XLMTM antibody, wu:fb19c01 antibody, zgc:123266 antibody, myotubularin 1 antibody, myotubularin 1 S homeolog antibody, MTM1 antibody, mtm1 antibody, mtm1.S antibody, Mtm1 antibody

背景

MTM1 is a member of a protein family that encodes tyrosine phosphatases. Myotubularin is required for muscle cell differentiation and mutations in MTM1 have been identified as being responsible for X-linked myotubular myopathy. MTM1 is a potent phosphatidylinositol 3-phosphate phosphatase (PI(3)P). Mutations in the MTM1 gene that cause human myotubular myopathy dramatically reduce the ability of the phosphatase to dephosphorylate PI(3)P. The findings provided evidence that myotubularin exerts its effects during myogenesis by regulating the cellular levels of the inositol lipid PI(3)P.

分子量

69932

NCBI登录号

NP_000243

UniProt

Q13496

途径

Inositol Metabolic Process, Skeletal Muscle Fiber Development