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MLLT10 抗体 (AA 294-323)

Name: MLLT10 抗体 (AA 294-323)
SKU: ABIN1882102
Availability: OutOfStock

MLLT10 适用: 人 WB, IF 宿主: 兔 Polyclonal RB8383 unconjugated

Western blot analysis of MLLT10 (ABIN1882102 and ABIN2850420) in K562 cell line lysates (35 μg/lane). (MLLT10 抗体 (AA 294-323))

Fluorescent confocal image of Hela cell stained with MLLT10 (AF10) Antibody (Center) (ABIN1882102 and ABIN2850420). (MLLT10 抗体 (AA 294-323))

2 images

(6 references)

产品编号 ABIN1882102

发货至: 中国

Datasheet as PDF

抗原 See all MLLT10 抗体

MLLT10 (Protein AF-10 (MLLT10))
抗原表位
16

8

4

4

3

2

2

1

1

1

1

1
AA 294-323
适用
48

19

13
人
宿主
46

3

1
兔
Compatible Secondaries
克隆类型
47

3
多克隆
标记
20

4

3

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This MLLT10 antibody is un-conjugated
应用范围
38

19

14

14

7

5

3

1

1
Western Blotting (WB), Immunofluorescence (IF)

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This MLLT10 (AF10) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 294-323 amino acids from the Central region of human MLLT10 (AF10).

克隆位点

RB8383

亚型

Ig Fraction
anti-Protein AF-10 (MLLT10) antibody
MLLT10 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Protein AF-10 (MLLT10) (AA 695-793) antibody
MLLT10 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2B9 unconjugated

anti-Protein AF-10 (MLLT10) (Internal Region) antibody
MLLT10 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Protein AF-10 (MLLT10) (Internal Region) antibody
MLLT10 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Protein AF-10 (MLLT10) (Internal Region) antibody
Verified MLLT10 适用: 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-Protein AF-10 (MLLT10) (AA 250-500) antibody
MLLT10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Protein AF-10 (MLLT10) (AA 998-1027), (C-Term) antibody
MLLT10 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB1930 unconjugated

anti-Protein AF-10 (MLLT10) (C-Term) antibody
MLLT10 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated

anti-Protein AF-10 (MLLT10) (AA 151-250) antibody
MLLT10 适用: 人, 大鼠 WB, FACS, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Protein AF-10 (MLLT10) (AA 151-250) antibody (Biotin)
MLLT10 适用: 人, 大鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal Biotin

应用备注

IF: 1:10~50. WB: 1:1000

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Benedikt, Baltruschat, Scholz, Bursen, Arrey, Meyer, Varagnolo, Müller, Karas, Dingermann, Marschalek: "The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures." in: Leukemia, Vol. 25, Issue 1, pp. 135-44, (2011) (PubMed).

Cai, Gao, Sheng, Miao, Cui, Wang, Zong, Koide: "Characterization and potential function of a novel testis-specific nucleoporin BS-63." in: Molecular reproduction and development, Vol. 61, Issue 1, pp. 126-34, (2002) (PubMed).

Perrin, Bloyer, Ferraz, Agrawal, Sinha, Dura: "The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions." in: Molecular and cellular biology, Vol. 23, Issue 1, pp. 119-30, (2002) (PubMed).

Roll, Zattara-Cannoni, Bustos-Bernard, Curtillet, Michel, Vagner-Capodano: "Molecular and fluorescence in situ hybridization analysis of a 10;11 rearrangement in a case of infant acute monocytic leukemia." in: Cancer genetics and cytogenetics, Vol. 135, Issue 2, pp. 187-91, (2002) (PubMed).

Nakamura, Mori, Tada, Krajewski, Rozovskaia, Wassell, Dubois, Mazo, Croce, Canaani: "ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation." in: Molecular cell, Vol. 10, Issue 5, pp. 1119-28, (2002) (PubMed).

Debernardi, Bassini, Jones, Chaplin, Linder, de Bruijn, Meese, Young: "The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex." in: Blood, Vol. 99, Issue 1, pp. 275-81, (2001) (PubMed).
抗原

MLLT10 (Protein AF-10 (MLLT10))

别名

MLLT10 (AF10) (MLLT10 产品)

别名

AF10 antibody, Af10 antibody, B130021D15Rik antibody, D630001B22Rik antibody, mKIAA4140 antibody, MLLT10, histone lysine methyltransferase DOT1L cofactor antibody, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 antibody, MLLT10 antibody, Mllt10 antibody

背景

Translocations affecting chromosome 11q23 involve many partner chromosome regions and occur in various leukemias. The 11q23 gene involved in the translocations is MLL. MLLT10 is the partner gene to MLL1 involved in t(10,11)(p12,q23) translocations. In an analysis of two leukemia patients, the in t(10,11)(p12,q23) translocation fuses MLL1, a SET domain containg histone methyltransferase, to the MLLT10 gene. The MLLT10 gene encodes a predicted 1,027-amino acid protein containing an N-terminal zinc finger and a C-terminal leucine zipper domain. The MLLT10 gene is one of the few MLL partner genes to be independently rearranged with a third gene in leukemia, the CALM gene in the t(10,11)(p12,q14) translocation. Chimeric fusion proteins MLL/AF10 and CALM/AF10 consistently retain the leucine zipper motif of MLLT10. The leucine zipper interacts with GAS41, a protein previously identified as the product of an amplified gene in a glioblastoma. GAS41 interacts with integrase interactor-1 (INI1), a component of the SWI/SNF complex, which acts to remodel chromatin and to modulate transcription. Retention of the leucine zipper in the MLL and CALM fusions suggested that a key feature of these chimeric proteins may be their ability to interfere in normal gene regulation through interaction with the adenosine triphosphate-dependent chromatin remodeling complexes.

分子量

113320

NCBI登录号

NP_001182555, NP_001182556, NP_001182557, NP_001182559, NP_004632

UniProt

P55197