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CSE1L 抗体 (N-Term)

CSE1L 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB9332 unconjugated
产品编号 ABIN1882070
发货至: 中国
  • 抗原 See all CSE1L products
    CSE1L (Chromosome Segregation 1-Like (CSE1L))
    抗原表位
    AA 55-84, N-Term
    适用
    • 9
    • 9
    • 7
    人, 小鼠
    宿主
    • 9
    克隆类型
    • 7
    • 2
    多克隆
    标记
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CSE1L antibody is un-conjugated
    应用范围
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    预测反应
    B, Zf
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This Cellular Apoptosis Susceptibility antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-84 amino acids from the N-terminal region of human Cellular Apoptosis Susceptibility.
    克隆位点
    RB9332
    亚型
    Ig Fraction
  • 应用备注
    IF: 1:100. WB: 1:1000. WB: 1:1000. IHC-P: 1:100. IHC-P: 1:100
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • Stella Tsai, Chen, Tung, Tsou, Tsao, Liao, Chen, Yeh, Yeh, Jiang: "Serum cellular apoptosis susceptibility protein is a potential prognostic marker for metastatic colorectal cancer." in: The American journal of pathology, Vol. 176, Issue 4, pp. 1619-28, (2010) (PubMed).

    Uen, Tai, Shen, Lee, Tsao, Deng, Chiou, Hsu, Hsieh, Liao, Jiang: "Differential distributions of CSE1L/CAS and E-cadherin in the polarized and non-polarized epithelial glands of neoplastic colorectal epithelium." in: Journal of molecular histology, Vol. 41, Issue 4-5, pp. 259-66, (2010) (PubMed).

    Tung, Tsai, Tung, Tsao, Chen, Yeh, Liao, Jiang: "Higher prevalence of secretory CSE1L/CAS in sera of patients with metastatic cancer." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 5, pp. 1570-7, (2009) (PubMed).

    Goldberg, Alexander, Pellicena, Zhang, Tsuda, Miller: "Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells." in: The Journal of biological chemistry, Vol. 278, Issue 47, pp. 46533-40, (2003) (PubMed).

    Behrens, Brinkmann, Wellmann: "CSE1L/CAS: its role in proliferation and apoptosis." in: Apoptosis : an international journal on programmed cell death, Vol. 8, Issue 1, pp. 39-44, (2003) (PubMed).

    Jiang, Liao, Tai: "CAS/CSE 1 stimulates E-cadhrin-dependent cell polarity in HT-29 human colon epithelial cells." in: Biochemical and biophysical research communications, Vol. 294, Issue 4, pp. 900-5, (2002) (PubMed).

    Wellmann, Flemming, Behrens, Wuppermann, Lang, Oldhafer, Pastan, Brinkmann: "High expression of the proliferation and apoptosis associated CSE1L/CAS gene in hepatitis and liver neoplasms: correlation with tumor progression." in: International journal of molecular medicine, Vol. 7, Issue 5, pp. 489-94, (2001) (PubMed).

    Brinkmann, Brinkmann, Bera, Wellmann, Pastan: "Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene." in: Genomics, Vol. 58, Issue 1, pp. 41-9, (1999) (PubMed).

  • 抗原
    CSE1L (Chromosome Segregation 1-Like (CSE1L))
    别名
    Cellular Apoptosis Susceptibility (CSE1L 产品)
    别名
    2610100P18Rik antibody, AA407533 antibody, Capts antibody, Cas antibody, Xpo2 antibody, cas antibody, chromosome segregation 1-like (S. cerevisiae) antibody, CSE1 chromosome segregation 1-like (yeast) antibody, Cse1l antibody, cse1l antibody
    背景
    Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, CSE1L may play a role both in apoptosis and in cell proliferation.
    分子量
    110417
    NCBI登录号
    NP_001243064, NP_001307
    UniProt
    P55060
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