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AGL 抗体 (AA 357-387)

AGL 适用: 人 WB, IF 宿主: 兔 Polyclonal RB4976 unconjugated
产品编号 ABIN1882062
发货至: 中国
  • 抗原 See all AGL 抗体
    AGL (Amylo-alpha-1, 6-Glucosidase, 4-alpha-Glucanotransferase (AGL))
    抗原表位
    • 8
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    AA 357-387
    适用
    • 33
    • 1
    宿主
    • 31
    • 2
    克隆类型
    • 33
    多克隆
    标记
    • 14
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This AGL antibody is un-conjugated
    应用范围
    • 18
    • 17
    • 16
    • 10
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This AGL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 357-387 amino acids from the Central region of human AGL.
    克隆位点
    RB4976
    亚型
    Ig Fraction
    Top Product
    Discover our top product AGL Primary Antibody
  • 应用备注
    IF: 1:10~50. WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • Irimia, Tagliabracci, Meyer, Segvich, DePaoli-Roach, Roach: "Muscle glycogen remodeling and glycogen phosphate metabolism following exhaustive exercise of wild type and laforin knockout mice." in: The Journal of biological chemistry, (2015) (PubMed).

    Guin, Ru, Agarwal, Ritterson Lew, Owens, Comi, Theodorescu: "Loss of glycogen debranching enzyme AGL drives bladder tumor growth via induction of hyaluronic acid synthesis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, (2015) (PubMed).

    DePaoli-Roach, Tagliabracci, Segvich, Meyer, Irimia, Roach: "Genetic depletion of the malin E3 ubiquitin ligase in mice leads to lafora bodies and the accumulation of insoluble laforin." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25372-81, (2010) (PubMed).

    Parker, Kong, Walsh, Salajegheh, Moghadaszadeh, Amato, Nazareno, Lin, Krastins, Sarracino, Beggs, Pinkus, Greenberg: "Fast-twitch sarcomeric and glycolytic enzyme protein loss in inclusion body myositis." in: Muscle & nerve, Vol. 39, Issue 6, pp. 739-53, (2009) (PubMed).

    Tagliabracci, Girard, Segvich, Meyer, Turnbull, Zhao, Minassian, Depaoli-Roach, Roach: "Abnormal metabolism of glycogen phosphate as a cause for Lafora disease." in: The Journal of biological chemistry, Vol. 283, Issue 49, pp. 33816-25, (2008) (PubMed).

    Cheng, Zhang, Gentry, Worby, Dixon, Saltiel: "A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease." in: Genes & development, Vol. 21, Issue 19, pp. 2399-409, (2007) (PubMed).

    Horinishi, Okubo, Tang, Hui, To, Mabuchi, Okada, Mabuchi, Murase: "Mutational and haplotype analysis of AGL in patients with glycogen storage disease type III." in: Journal of human genetics, Vol. 47, Issue 2, pp. 55-9, (2002) (PubMed).

    Bao, Dawson, Chen: "Human glycogen debranching enzyme gene (AGL): complete structural organization and characterization of the 5' flanking region." in: Genomics, Vol. 38, Issue 2, pp. 155-65, (1997) (PubMed).

    Hansen, Lundin, Markussen, Thorsby: "T cell receptor usage by HLA-DQw8-specific T cell clones." in: International immunology, Vol. 4, Issue 8, pp. 931-4, (1992) (PubMed).

    Yang, Ding, Enghild, Bao, Chen: "Molecular cloning and nucleotide sequence of cDNA encoding human muscle glycogen debranching enzyme." in: The Journal of biological chemistry, Vol. 267, Issue 13, pp. 9294-9, (1992) (PubMed).

  • 抗原
    AGL (Amylo-alpha-1, 6-Glucosidase, 4-alpha-Glucanotransferase (AGL))
    别名
    AGL (AGL 产品)
    别名
    DDBDRAFT_0219237 antibody, DDBDRAFT_0234114 antibody, DDB_0219237 antibody, DDB_0234114 antibody, GDE antibody, 1110061O17Rik antibody, 9430004C13Rik antibody, 9630046L06Rik antibody, AI850929 antibody, C77197 antibody, amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase antibody, glycogen debranching enzyme antibody, glycogen debranching protein antibody, amylo-1,6-glucosidase, 4-alpha-glucanotransferase antibody, AGL antibody, agl antibody, MMAH_RS03870 antibody, Agl antibody
    背景
    AGL is a glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in the AGL gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing.
    分子量
    174764
    NCBI登录号
    NP_000019, NP_000633, NP_000634, NP_000635, NP_000636, NP_000637
    UniProt
    P35573
    途径
    Cellular Glucan Metabolic Process
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