(5 references)-
- 抗原 See all SH2D1A 抗体
- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
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抗原表位
- AA 85-114, C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SH2D1A antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This SH2D1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-114 amino acids from the C-terminal region of human SH2D1A.
- 克隆位点
- RB41923
- 亚型
- Ig Fraction
- Top Product
- Discover our top product SH2D1A Primary Antibody
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anti-SH2 Domain Containing 1A (SH2D1A) (AA 1-128) antibody
SH2D1A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C9 unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (AA 1-128) antibodySH2D1A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (AA 11-124) antibodySH2D1A 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (C-Term) antibodySH2D1A 适用: 人, 猴, 兔, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (AA 18-115) antibodySH2D1A 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (AA 1-128) antibodySH2D1A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (Internal Region) antibodyVerified SH2D1A 适用: 人 WB, ELISA, IP 宿主: 山羊 Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) antibodySH2D1A 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (C-Term) antibodySH2D1A 适用: 人, 大鼠, Pig, Cow, 马 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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: "Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency." in: The Journal of clinical investigation, Vol. 119, Issue 10, pp. 2976-89, (2009) (PubMed).
: "The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 29, pp. 11966-71, (2009) (PubMed).
: "SAP binds to CD22 and regulates B cell inhibitory signaling and calcium flux." in: Cellular signalling, Vol. 21, Issue 4, pp. 540-50, (2009) (PubMed).
: "Customised molecular diagnosis of primary immune deficiency disorders in New Zealand: an efficient strategy for a small developed country." in: The New Zealand medical journal, Vol. 122, Issue 1304, pp. 46-53, (2009) (PubMed).
: "SLAM receptors and SAP influence lymphocyte interactions, development and function." in: Nature reviews. Immunology, Vol. 9, Issue 1, pp. 39-46, (2008) (PubMed).
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: "Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency." in: The Journal of clinical investigation, Vol. 119, Issue 10, pp. 2976-89, (2009) (PubMed).
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- 抗原
- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
- 别名
- SH2D1A (SH2D1A 产品)
- 别名
- DSHP antibody, EBVS antibody, IMD5 antibody, LYP antibody, MTCP1 antibody, SAP antibody, SAP/SH2D1A antibody, XLP antibody, XLPD antibody, RGD1562408 antibody, Gm686 antibody, SH2D1A antibody, SH2 domain containing 1A antibody, SH2D1A antibody, Sh2d1a antibody
- 背景
- This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
- 分子量
- 14187
- NCBI登录号
- NP_001108409, NP_002342
- UniProt
- O60880
- 途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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