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CDK4 抗体 (C-Term)

Name: CDK4 抗体 (C-Term)
SKU: ABIN1881714
Availability: OutOfStock

CDK4 适用: 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated

Rat Cdk4 Antibody (C-term) (ABIN1881714 and ABIN2843623) western blot analysis in rat lung tissue lysates (35 μg/lane). (CDK4 抗体 (C-Term))

Immunohistochemical analysis of paraffin-embedded rat small intestine section using Rat Cdk4 Antibody (C-term) B. (CDK4 抗体 (C-Term))

IHC (p)

Fluorescent image of MCF-7 cells stained with (Rat) Cdk4 Antibody (C-term) B. (CDK4 抗体 (C-Term))

Immunohistochemical analysis of paraffin-embedded R. (CDK4 抗体 (C-Term))

IHC (p)

4 images

(1 reference)

产品编号 ABIN1881714

发货至: 中国

Datasheet as PDF

抗原 See all CDK4 抗体

CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
抗原表位
18

16

15

9

9

8

5

5

4

4

3

3

2

2

2

2

2

2

1

1

1

1

1
AA 272-303, C-Term
适用
108

66

50

19

8

6

4

3

2

1

1

1
大鼠
宿主
93

34

2

1
兔
Compatible Secondaries
克隆类型
96

33
多克隆
标记
75

10

9

5

5

4

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This CDK4 antibody is un-conjugated
应用范围
107

48

32

24

16

15

15

13

13

10

4

4

2

2

1

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This Rat Cdk4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-303 amino acids from the C-terminal region of rat Cdk4.

亚型

Ig Fraction

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anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 201-303) antibody
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anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 273-305) antibody
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anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 241-303) antibody
CDK4 适用: 人, 小鼠, 大鼠, 绵羊 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 272-303) antibody
CDK4 适用: 人, 大鼠 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (C-Term) antibody
CDK4 适用: 人, 大鼠, 绵羊, Pig, 犬, Cow, 兔, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

IF: 1:25. WB: 1:1000. IHC-P: 1:25. IHC-P: 1:25

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Cho, Phillips, Khan, Weaver: "Cloning of the rat cyclin-dependent kinase 4 cDNA: implication in proliferation-dependent expression in rat tissues." in: Biochemical and biophysical research communications, Vol. 191, Issue 3, pp. 860-5, (1993) (PubMed).
抗原

CDK4 (Cyclin-Dependent Kinase 4 (CDK4))

别名

Cdk4 (CDK4 产品)

别名

zgc:153726 antibody, CMM3 antibody, PSK-J3 antibody, Crk3 antibody, 8-6 antibody, CDK4 antibody, CDK4/6 antibody, CG5072 antibody, Cdk4/6 antibody, DmCdk4 antibody, Dmel\\CG5072 antibody, Pk53C antibody, Pk?7 antibody, cdk antibody, cdk4 antibody, cdk4/6 antibody, dCdk4 antibody, l(2)05428 antibody, l(2)0671 antibody, l(2)k06503 antibody, l(2)s4639 antibody, l(2)sh0671 antibody, xcdk4 antibody, cyclin-dependent kinase 4 antibody, cyclin dependent kinase 4 antibody, Cyclin-dependent kinase 4 antibody, cyclin-dependent kinase 4 L homeolog antibody, cdk4 antibody, CDK4 antibody, Cdk4 antibody, cdk4.L antibody

背景

Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

分子量

33799

NCBI登录号

NP_446045

UniProt

P35426

途径

Cell Division Cycle, Mitotic G1-G1/S Phases, Regulation of Cell Size