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IKK alpha 抗体 (N-Term)

CHUK 适用: 人 WB 宿主: 兔 Polyclonal RB41290 unconjugated
产品编号 ABIN1881203
发货至: 中国
  • 抗原 See all IKK alpha (CHUK) 抗体
    IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))
    抗原表位
    • 18
    • 15
    • 15
    • 12
    • 11
    • 11
    • 8
    • 8
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    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    • 1
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    • 1
    AA 84-112, N-Term
    适用
    • 131
    • 75
    • 54
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    宿主
    • 146
    • 12
    • 1
    克隆类型
    • 139
    • 20
    多克隆
    标记
    • 79
    • 15
    • 9
    • 9
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
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    • 2
    This IKK alpha antibody is un-conjugated
    应用范围
    • 125
    • 73
    • 42
    • 27
    • 26
    • 18
    • 15
    • 13
    • 13
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB)
    预测反应
    B, C, M
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This CHUK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-112 amino acids from the N-terminal region of human CHUK.
    克隆位点
    RB41290
    亚型
    Ig Fraction
    Top Product
    Discover our top product CHUK Primary Antibody
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • Lahtela, Nousiainen, Stefanovic, Tallila, Viskari, Karikoski, Gentile, Saloranta, Varilo, Salonen, Kestilä: "Mutant CHUK and severe fetal encasement malformation." in: The New England journal of medicine, Vol. 363, Issue 17, pp. 1631-7, (2010) (PubMed).

    Gouin, Adib-Conquy, Balestrino, Nahori, Villiers, Colland, Dramsi, Dussurget, Cossart: "The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 40, pp. 17333-8, (2010) (PubMed).

    Cummins, Oliver, Lenihan, Fitzpatrick, Bruning, Scholz, Slattery, Leonard, McLoughlin, Taylor: "NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 4439-45, (2010) (PubMed).

    Li, Morgan, Choksi, Zhang, Kim, Liu: "MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation." in: Nature immunology, Vol. 11, Issue 9, pp. 799-805, (2010) (PubMed).

    Rotman, Koh, Zmuda, Kleiner, Liang: "The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease." in: Hepatology (Baltimore, Md.), Vol. 52, Issue 3, pp. 894-903, (2010) (PubMed).

  • 抗原
    IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))
    别名
    CHUK (CHUK 产品)
    别名
    ikk antibody, ikk1 antibody, ikka antibody, ikkalpha antibody, CHUK antibody, IKBKA antibody, IKK-alpha antibody, IKK1 antibody, IKKA antibody, NFKBIKA antibody, TCF16 antibody, AI256658 antibody, Chuk1 antibody, Fbx24 antibody, Fbxo24 antibody, Ikka antibody, zgc:56539 antibody, conserved helix-loop-helix ubiquitous kinase S homeolog antibody, conserved helix-loop-helix ubiquitous kinase antibody, chuk.S antibody, CHUK antibody, Chuk antibody, chuk antibody
    背景
    This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
    分子量
    84640
    NCBI登录号
    NP_001269
    UniProt
    O15111
    途径
    PI3K-Akt Signaling, NF-kappaB Signaling, RTK signaling, TCR Signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins
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