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CCR5 抗体 (AA 151-177)

CCR5 适用: 人 WB 宿主: 兔 Polyclonal RB41438 unconjugated
产品编号 ABIN1881182
发货至: 中国
  • 抗原 See all CCR5 抗体
    CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
    抗原表位
    • 16
    • 13
    • 11
    • 8
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 151-177
    适用
    • 145
    • 44
    • 36
    • 10
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 105
    • 32
    • 13
    • 4
    • 1
    克隆类型
    • 108
    • 41
    • 3
    多克隆
    标记
    • 82
    • 13
    • 11
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CCR5 antibody is un-conjugated
    应用范围
    • 92
    • 69
    • 58
    • 21
    • 17
    • 17
    • 16
    • 14
    • 14
    • 13
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB)
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This CCR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-177 amino acids from the Central region of human CCR5.
    克隆位点
    RB41438
    亚型
    Ig Fraction
    Top Product
    Discover our top product CCR5 Primary Antibody
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • Gérard, Stanich, Oszust, Whittum-Hudson, Carter, Schumacher, Hudson: "Functional CCR5 receptor protects patients with arthritis from high synovial burden of infecting Chlamydia trachomatis." in: The American journal of the medical sciences, Vol. 340, Issue 6, pp. 448-51, (2010) (PubMed).

    Hammad, Kuang, Yan, Allen, Dupré: "Na+/H+ exchanger regulatory factor-1 is involved in chemokine receptor homodimer CCR5 internalization and signal transduction but does not affect CXCR4 homodimer or CXCR4-CCR5 heterodimer." in: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34653-64, (2010) (PubMed).

    Martens, Gross, van der Steege, Brouwer, Berden, de Sevaux, Derksen, Voskuyl, Berger, Navis, Kallenberg, Bijl: "Lack of association of C-C chemokine receptor 5 Δ32 deletion status with rheumatoid arthritis, systemic lupus erythematosus, lupus nephritis, and disease severity." in: The Journal of rheumatology, Vol. 37, Issue 11, pp. 2226-31, (2010) (PubMed).

    Weng, Chien, Lin, Chung, Zavras, Tsai, Chen, Yang: "Effect of CC chemokine ligand 5 and CC chemokine receptor 5 genes polymorphisms on the risk and clinicopathological development of oral cancer." in: Oral oncology, Vol. 46, Issue 10, pp. 767-72, (2010) (PubMed).

  • 抗原
    CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
    别名
    CCR5 (CCR5 产品)
    别名
    CC-CKR-5 antibody, CCCKR5 antibody, CCR-5 antibody, CD195 antibody, CKR-5 antibody, CKR5 antibody, CMKBR5 antibody, IDDM22 antibody, Ckr5 antibody, Cmkbr5 antibody, CCR1-L antibody, GPCR antibody, CCR5 antibody, AM4-7 antibody, C-C motif chemokine receptor 5 (gene/pseudogene) antibody, chemokine (C-C motif) receptor 5 antibody, C-C motif chemokine receptor 5 antibody, CCR5 antibody, Ccr5 antibody
    背景
    This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.
    分子量
    40524
    NCBI登录号
    NP_000570, NP_001093638
    UniProt
    P51681
    途径
    Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size
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