BcDNA:SD07139 antibody, CG5874 antibody, Dmel\\CG5874 antibody, NELF antibody, NELF-A antibody, Whsc2 antibody, fi75f03 antibody, whsc2 antibody, wu:fi75f03 antibody, MGC85474 antibody, WHSC2 antibody, nelfa antibody, nelf-a antibody, p/okcl.15 antibody, Whsc2h antibody, Negative elongation factor A antibody, negative elongation factor complex member A antibody, negative elongation factor complex member A L homeolog antibody, negative elongation factor complex member A, Whsc2 antibody, Nelf-A antibody, Nelfa antibody, nelfa antibody, nelfa.L antibody, NELFA antibody
背景
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues.It encodes a protein sharing 93% sequence identity with the mouse protein.Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4.This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome.The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients.This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.