This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain.Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus.This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase.Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.