Sortilin 1 抗体 (C-Term)
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- 抗原 See all Sortilin 1 (SORT1) 抗体
- Sortilin 1 (SORT1)
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抗原表位
- C-Term
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适用
- 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Sortilin 1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- Specific for Sortilin.
- 免疫原
- A synthetic peptide from the extracellular, c-terminal region of rat Sortilin (Neurotensin receptor 3, NTR3, Sort1) conjugated to immunogenic carrier protein was used as the antigen.
- 亚型
- IgG
- Top Product
- Discover our top product SORT1 Primary Antibody
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anti-Sortilin 1 (SORT1) (AA 203-299) antibody
SORT1 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1B3 unconjugated
anti-Sortilin 1 (SORT1) (AA 520-760) antibodySORT1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sortilin 1 (SORT1) (AA 328-457) antibodySORT1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sortilin 1 (SORT1) (AA 320-335), (Extracellular Domain) antibodySORT1 适用: 人, 大鼠, 小鼠 WB, IHC, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-Sortilin 1 (SORT1) (AA 731-831) antibodySORT1 适用: 人, 大鼠, 小鼠 ELISA, WB, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Sortilin 1 (SORT1) (AA 50-320) antibodySORT1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sortilin 1 (SORT1) (AA 203-299) antibodySORT1 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Sortilin 1 (SORT1) (AA 320-335), (Extracellular Domain) antibody (FITC)SORT1 适用: 人, 大鼠, 小鼠 FACS 宿主: 兔 Polyclonal FITC
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- 应用备注
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A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications. - 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- 注意事项
- Avoid freeze and thaw cycles.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
- 有效期
- 12 months
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- 抗原
- Sortilin 1 (SORT1)
- 别名
- Sortilin (SORT1 产品)
- 别名
- SORT1 antibody, 19.m02079 antibody, gp95 antibody, ldlcq6 antibody, sortilin antibody, Gp95 antibody, LDLCQ6 antibody, NT3 antibody, 2900053A11Rik antibody, AI852375 antibody, Ntr3 antibody, Ntsr3 antibody, Nt3 antibody, Nts3 antibody, sort1 antibody, zgc:85953 antibody, sortilin 1 antibody, sortilin antibody, sortilin 1 S homeolog antibody, sortilin 1a antibody, SORT1 antibody, TP01_0016 antibody, BBOV_I002730 antibody, sort1.S antibody, Sort1 antibody, sort1a antibody
- 背景
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FUNCTION: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. SUBUNIT: Interacts with the cytosolic adapter proteins GGA1 and GGA2. Interacts with numerous ligands including the receptor-associated protein LRPAP1/RAP and GM2A, LPL, PSAP and SLC2A4. Forms a complex with NGFR which binds specifically to the precursor form of NGFB (proNGFB). Interacts with the precursor form of BDNF (proBDNF). SUBCELLULAR LOCATION: Membrane, Single-pass type I membrane protein. Note: Localized to membranes of the endosomes, Golgi stack, lysosomes and nucleus. Localization to the plasma membrane in adipocytes is enhanced by insulin. Localized to the endoplasmic reticulum and the plasma membrane. Also found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. TISSUE SPECIFICITY: Highly expressed in fat, brain, and lung. Expressed in neuronal bodies and dendrites of the piriform cortex and hippocampus. Also expressed in the islands of Calleja, medial and lateral septal nuclei, amygdaloid nuclei, thalamic nuclei, the supraoptic nucleus, the substantia nigra, the Purkinje layer of the cerebellar cortex and the cranial motor nerve nuclei of the brainstem.
Synonyms: Neurotensin receptor 3, NTR3, Glycoprotein 110, Gp110, Nt3, Nts3 - 途径
- Neurotrophin Signaling Pathway
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