Complement C8 抗体
C8
适用: 人
FACS, WB, EIA, IHC (fro)
宿主: 小鼠
Monoclonal
056B-373
unconjugated
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- 抗原 See all Complement C8 (C8) products
- Complement C8 (C8)
- 适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Complement C8 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- This antibody recognizes complement component 8 (C8), a 151 kDa member of the complement C6/C7/C8/C9 family, present in blood serum.
- 交叉反应 （详细）
- Species reactivity (tested):Human.
- 产品特性
- Synonyms: Complement component C8, Complement 8
- 纯化方法
- Affinity Chromatography on Protein A
- 免疫原
- Purified Human C8. Genename: C8
- 克隆位点
- 056B-373
- 亚型
- IgG1
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- 应用备注
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ELISA. Western Blot. Flow Cytometry. Immunohistochemistry on Frozen Sections. Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Borate buffered saline pH 8.2-8.4 containing 0.02 % Sodium Azide as preservative.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. - 有效期
- 12 months
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- 抗原
- Complement C8 (C8)
- 别名
- Complement C8 (C8 产品)
- 背景
- C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyses the polymerization of C9 Molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane. Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.Synonyms: Complement 8, Complement component C8
- 基因ID
- 732
- UniProt
- P07358
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