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Clusterin 抗体

CLU 适用: 人 WB, FACS, EIA, IHC (fro) 宿主: 小鼠 Monoclonal 3R3-2 unconjugated
产品编号 ABIN181112
发货至: 中国
  • 抗原 See all Clusterin (CLU) 抗体
    Clusterin (CLU)
    适用
    • 90
    • 28
    • 27
    • 12
    • 7
    • 6
    • 2
    • 1
    • 1
    • 1
    宿主
    • 82
    • 40
    • 7
    • 5
    • 2
    • 1
    小鼠
    克隆类型
    • 94
    • 41
    • 1
    单克隆
    标记
    • 80
    • 25
    • 17
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Clusterin antibody is un-conjugated
    应用范围
    • 111
    • 67
    • 57
    • 23
    • 22
    • 19
    • 18
    • 13
    • 8
    • 6
    • 6
    • 6
    • 3
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    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    This antibody recognises clusterin, an ubiquitously expressed protein of two 40- kDa chains, alpha and beta, covalently joined by disulfide bonds.
    产品特性
    Synonyms: Clusterin, APOJ, CLI, KUB1, AAG4, NA1/NA2, SP-40, 40, Complement-associated proteinSP-40, Complement cytolysis inhibitor, Testosterone-repressed prostate message 2,Ku70-binding protein 1, Aging-associated gene 4 protein
    纯化方法
    Affinity chromatography on Protein A
    免疫原
    Glomerular basement membrane from a post-mortem kidney.
    克隆位点
    3R3-2
    亚型
    IgG1
    Top Product
    Discover our top product CLU Primary Antibody
  • 应用备注
    ELISA. Western Blot. Flow Cytometry. Immunohistochemistry on frozen sections. Recommended Positive Control: Kidney from post streptocial glomerulonephritis patients.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    Borate buffered saline pH 8.4 containing 0.02 % Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    有效期
    12 months
  • 抗原
    Clusterin (CLU)
    别名
    Apolipoprotein J (Apo J) (CLU 产品)
    背景
    Clusterin exists in two forms, a pro-apoptotic form localised to the nucleus and a pro-survival secreted form. Both are thought to be involved in DNA repair and cell cycle regulation. The secreted form is thought to inhibit apoptotic signalling by BAX, Clusterin suppression can sensitise cells to chemotherapy. Clusterin is overexpressed in human prostate cancer, breast cancers and squamous cell carcinomas. Part of the SC5b-9 complex, clusterin prevents the binding of a C5b-C7 complex to the membrane of the target cell inhibiting the complement cascade. Clusterin acts as an extracellular chaperone inhibiting the formation of human lysozyme amyloid associated with Alzheimers disease. Clusterin is also important in spermatogenesis and is secreted by Sertoli cells.Synonyms: 40, 40, AAG4, APOJ, Aging-associated gene 4 protein, CLI, Clusterin, Complement cytolysis inhibitor, Complement-associated protein SP-40, KUB1, Ku70-binding protein 1, NA1/NA2, SP-40, Testosterone-repressed prostate message 2
    基因ID
    1191
    UniProt
    P10909
    途径
    Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
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