Soluble Terminal Complement Complex (sC5b-9) 抗体
sC5b-9
适用: 人
FACS, IHC (fro), WB, EIA
宿主: 小鼠
Monoclonal
3R2-0
unconjugated
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- 抗原
- Soluble Terminal Complement Complex (sC5b-9)
- 适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- 非结合性
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应用范围
- Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB), Enzyme Immunoassay (EIA)
- 产品特性
- Synonyms: Terminal complement complex, Membrane attack complex
- 纯化方法
- Affinity Chromatography on Protein A
- 克隆位点
- 3R2-0
- 亚型
- IgG2b
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- 应用备注
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ELISA. Western Blot. Flow Cytometry. Immunohistochemistry on frozen sections. Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Borate buffered saline, pH 8.4 containing 0.09 % Sodium Azide as preservative
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. - 有效期
- 12 months
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- 抗原
- Soluble Terminal Complement Complex (sC5b-9)
- 别名
- Complement SC5b-9 (TCC / MAC)
- 背景
- Both the classical and alternative complement pathways result in the formation of the cytolysis inducing C5b-9 complex. This complex is composed of 190 kDa C5b which is bound to cells via 71 kDa C9. Sublytic assembly of C5b-9 on plasma membranes induces cell cycle activation and survival. The binding of C5b-9 to the 75 kDa S-protein (or vitronectin) in the fluid phase prevents C5b-9 from assembling on the plasma membrane, deactivating it and forming the SC5b-9 complex. SC5b-9 is stable in vitro and is therefore a reliable indicator of terminal complement pathway activation.Synonyms: Membrane attack complex, Terminal complement complex
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