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FcRn 抗体

Name: FcRn 抗体
Brand: antibodies-online
SKU: ABIN1774763
Availability: OutOfStock

FcRn 适用: 人 ELISA, IF, FACS, cELISA 宿主: 小鼠 Monoclonal DVN24 unconjugated

Immunofluorescence: huSSECTM cell line overexpressing hFcRn-EGFP using clone DVN24 at 15µg/ml and Texas Red™ conjugated anti-mouse secondary. (FcRn 抗体)

293hFcRn-GFP cells were incubated with a range of concentrations of DVN1, ADM11, DVN21, DVN22, DVN23, DVN24, ADM31 or ADM32 at pH 6, then stained for functional binding with (A) 20 μg/mL hIgGAF647, or (B) 200 μg/mL HSAbiotin followed by streptavidin-PE. (FcRn 抗体)

FACS

ELISA

Immunofluorescence staining of huSSECTM cell line overexpressing hFcRn-EGFP using clone DVN24 at 15µg/ml and Texas Red™ conjugated anti-mouse secondary. (FcRn 抗体)

Flowcytometry of huSSECTM cell line overexpressing hFcRn-EGFP labeled with clone DVN24 primary Ab and Texas Red™ conjugated anti-mouse secondary. (FcRn 抗体)

FACS

6 images

(6 references)

产品编号 ABIN1774763

发货至: 中国

Datasheet as PDF

Key Features
- High-quality FcRn antibody (Clone DVN24) for the detection of FcRn.
- Highly specific for human FcRn, blocks the binding of IgG.
- PBS-only, preservative free
- 2 PubMed references available for this FcRn antibody.
抗原 See all FcRn 抗体

FcRn (IgG receptor FcRn (FcRn))
适用
42

4

4

1

1

1

1

1
人
宿主
39

8

1
小鼠
Compatible Secondaries
克隆类型
40

8
单克隆
标记
23

5

5

5

2

2

1

1

1

1

1

1
This FcRn antibody is un-conjugated
应用范围
28

27

6

6

5

3

2

2

2

1

1

1

1

1
ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Cell-ELISA (cELISA)

产品特性

based on recognition of the complete native protein expressed on transfected mammalian cells

纯化方法

Purified, Protein G

免疫原

hFcRn

克隆位点

DVN24

亚型

IgG2a kappa

Top Product

Discover our top product FcRn Primary Antibody

Product Specific Information

Limited uses of our FcRn antibody ABIN1774763 / DVN24
anti-IgG receptor FcRn (FcRn) antibody
FcRn 适用: 人 ELISA, IF, FACS, cELISA, Func 宿主: 小鼠 Monoclonal ADM31 unconjugated

anti-IgG receptor FcRn (FcRn) antibody
FcRn 适用: 人 ELISA, IF, FACS, cELISA 宿主: 小鼠 Monoclonal DVN24 unconjugated

anti-IgG receptor FcRn (FcRn) (AA 24-297) antibody
FcRn 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-IgG receptor FcRn (FcRn) antibody
FcRn 适用: 人 ELISA, IF, FACS, cELISA, Func 宿主: 小鼠 Monoclonal ADM31 unconjugated

anti-IgG receptor FcRn (FcRn) (AA 24-365) antibody
FcRn 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-IgG receptor FcRn (FcRn) (AA 24-215) antibody
FcRn 适用: 人 IHC, ISt, StM 宿主: 小鼠 Monoclonal FCGRT-2932 unconjugated

anti-IgG receptor FcRn (FcRn) (AA 24-297) antibody
FcRn 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 2B3B11 unconjugated

anti-IgG receptor FcRn (FcRn) (AA 24-297) antibody
FcRn 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 5F3D1 unconjugated

anti-IgG receptor FcRn (FcRn) (AA 25-300) antibody
FcRn 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-IgG receptor FcRn (FcRn) (N-Term) antibody
FcRn 适用: 人, 小鼠, Cow, 犬, 豚鼠, 马, 绵羊 WB, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

Flow cytometry: 1.2 μg/10^6 cells ELISA: 1:200 - 1:400CELISA: 1:200 - 1:400For each application a titration should be performed to determine the optimal concentration.

限制

仅限研究用
缓冲液

PBS pH 7.2

注意事项

avoid repeated freezing and thawing

储存条件

4 °C
Xu, He, Momben-Abolfath, Vertrees, Li, Norton, Struble: "Zika Virus Infection and Antibody Neutralization in FcRn Expressing Placenta and Engineered Cell Lines." in: Vaccines, Vol. 10, Issue 12, (2022) (PubMed).

Hubbard, Pyzik, Rath, Kozicky, Sand, Gandhi, Grevys, Foss, Menzies, Glickman, Fiebiger, Roopenian, Sandlie, Andersen, Sly, Baker, Blumberg: "FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity." in: The Journal of experimental medicine, Vol. 217, Issue 10, (2021) (PubMed).

Cines, Zaitsev, Rauova, Rux, Stepanova, Krishnaswamy, Sarkar, Kowalska, Zhao, Mast, Blumberg, McCrae, Poncz, Hubbard, Pyzik, Blumberg: "FcRn augments induction of tissue factor activity by IgG-containing immune complexes." in: Blood, Vol. 135, Issue 23, pp. 2085-2093, (2021) (PubMed).

Grevys, Nilsen, Sand, Daba, Øynebråten, Bern, McAdam, Foss, Schlothauer, Michaelsen, Christianson, Roopenian, Blumberg, Sandlie, Andersen: "A human endothelial cell-based recycling assay for screening of FcRn targeted molecules." in: Nature communications, Vol. 9, Issue 1, pp. 621, (2018) (PubMed).

Christianson, Sun, Akilesh, Pesavento, Proetzel, Roopenian: "Monoclonal antibodies directed against human FcRn and their applications." in: mAbs, Vol. 4, Issue 2, pp. 208-16, (2014) (PubMed).

Sand, Dalhus, Christianson, Bern, Foss, Cameron, Sleep, Bjørås, Roopenian, Sandlie, Andersen: "Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies." in: The Journal of biological chemistry, Vol. 289, Issue 24, pp. 17228-39, (2014) (PubMed).
抗原

FcRn (IgG receptor FcRn (FcRn))

Abstract

FcRn 产品

别名

FCRN antibody, alpha-chain antibody, FcRn antibody, Fc fragment of IgG receptor and transporter antibody, Fc receptor, IgG, alpha chain transporter antibody, FCGRT antibody, Fcgrt antibody

背景

The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers. By performing these functions, FcRn affects numerous facets of antibody biology and pathobiology. Its critical role in controlling IgG pharmacokinetics has been leveraged for the design of therapeutic antibodies and related biologics. FcRn also traffics serum albumin and is responsible for the enhanced pharmacokinetic properties of albumin-conjugated therapeutics.
Synonyms: IgG receptor FcRn large subunit p51, Neonatal Fc receptor, FCGRT

UniProt

P55899

途径

Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process