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FcRn 抗体

FcRn 适用: 人 ELISA, IF, FACS, cELISA 宿主: 小鼠 Monoclonal DVN24 unconjugated
产品编号 ABIN1774763
发货至: 中国
  • Key Features
    • High-quality FcRn antibody (Clone DVN24) for the detection of FcRn.
    • Highly specific for human FcRn, blocks the binding of IgG.
    • PBS-only, preservative free
    • 2 PubMed references available for this FcRn antibody.
    抗原 See all FcRn 抗体
    FcRn (IgG receptor FcRn (FcRn))
    适用
    • 42
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    宿主
    • 39
    • 8
    • 1
    小鼠
    克隆类型
    • 40
    • 8
    单克隆
    标记
    • 23
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
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    This FcRn antibody is un-conjugated
    应用范围
    • 30
    • 27
    • 8
    • 6
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    ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Cell-ELISA (cELISA)
    产品特性
    based on recognition of the complete native protein expressed on transfected mammalian cells
    纯化方法
    Purified, Protein G
    免疫原
    hFcRn
    克隆位点
    DVN24
    亚型
    IgG2a kappa
    Top Product
    Discover our top product FcRn Primary Antibody
  • 应用备注
    Flow cytometry: 1.2 μg/10^6 cells ELISA: 1:200 - 1:400CELISA: 1:200 - 1:400For each application a titration should be performed to determine the optimal concentration.
    限制
    仅限研究用
  • 缓冲液
    PBS pH 7.2
    注意事项
    avoid repeated freezing and thawing
    储存条件
    4 °C
  • Xu, He, Momben-Abolfath, Vertrees, Li, Norton, Struble: "Zika Virus Infection and Antibody Neutralization in FcRn Expressing Placenta and Engineered Cell Lines." in: Vaccines, Vol. 10, Issue 12, (2022) (PubMed).

    Hubbard, Pyzik, Rath, Kozicky, Sand, Gandhi, Grevys, Foss, Menzies, Glickman, Fiebiger, Roopenian, Sandlie, Andersen, Sly, Baker, Blumberg: "FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity." in: The Journal of experimental medicine, Vol. 217, Issue 10, (2021) (PubMed).

    Cines, Zaitsev, Rauova, Rux, Stepanova, Krishnaswamy, Sarkar, Kowalska, Zhao, Mast, Blumberg, McCrae, Poncz, Hubbard, Pyzik, Blumberg: "FcRn augments induction of tissue factor activity by IgG-containing immune complexes." in: Blood, Vol. 135, Issue 23, pp. 2085-2093, (2021) (PubMed).

    Grevys, Nilsen, Sand, Daba, Øynebråten, Bern, McAdam, Foss, Schlothauer, Michaelsen, Christianson, Roopenian, Blumberg, Sandlie, Andersen: "A human endothelial cell-based recycling assay for screening of FcRn targeted molecules." in: Nature communications, Vol. 9, Issue 1, pp. 621, (2018) (PubMed).

    Christianson, Sun, Akilesh, Pesavento, Proetzel, Roopenian: "Monoclonal antibodies directed against human FcRn and their applications." in: mAbs, Vol. 4, Issue 2, pp. 208-16, (2014) (PubMed).

    Sand, Dalhus, Christianson, Bern, Foss, Cameron, Sleep, Bjørås, Roopenian, Sandlie, Andersen: "Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies." in: The Journal of biological chemistry, Vol. 289, Issue 24, pp. 17228-39, (2014) (PubMed).

  • 抗原
    FcRn (IgG receptor FcRn (FcRn))
    Abstract
    FcRn 产品
    别名
    FCRN antibody, alpha-chain antibody, FcRn antibody, Fc fragment of IgG receptor and transporter antibody, Fc receptor, IgG, alpha chain transporter antibody, FCGRT antibody, Fcgrt antibody
    背景
    The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers. By performing these functions, FcRn affects numerous facets of antibody biology and pathobiology. Its critical role in controlling IgG pharmacokinetics has been leveraged for the design of therapeutic antibodies and related biologics. FcRn also traffics serum albumin and is responsible for the enhanced pharmacokinetic properties of albumin-conjugated therapeutics.
    Synonyms: IgG receptor FcRn large subunit p51, Neonatal Fc receptor, FCGRT
    UniProt
    P55899
    途径
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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