NrCAM 抗体 (Extracellular Domain)
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- 抗原 See all NrCAM (NRCAM) 抗体
- NrCAM (NRCAM) (Neuronal Cell Adhesion Molecule (NRCAM))
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抗原表位
- AA 30-845, Extracellular Domain
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适用
- 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This NrCAM antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
- 特异性
- Detects ~160 kDa.
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Protein G Purified
- 免疫原
- Fusion protein amino acids 30-845 (extracellular domain) of mouse NrCAM. Rat: 96% identity (795/822 amino acids identical). Human: 91% identity (753/822 amino acids identical) ~50% identity with Neurofascin.
- 克隆位点
- S364-51
- 亚型
- IgG2a
- Top Product
- Discover our top product NRCAM Primary Antibody
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anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 1192-1255) antibody
NRCAM 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 7D8C5 unconjugated
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 1194-1299) antibodyNRCAM 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (HRP)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 HRP
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (FITC)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 FITC
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (Alkaline Phosphatase (AP))NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 Alkaline Phosphatase (AP)
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (Biotin)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 Biotin
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (PE)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 PE
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (APC)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 APC
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (PerCP)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 PerCP
anti-Neuronal Cell Adhesion Molecule (NRCAM) (AA 30-845), (Extracellular Domain) antibody (Atto 488)NRCAM 适用: 小鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S364-51 Atto 488
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- 应用备注
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- WB (1:1000)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
- 说明
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1 μg/ml of ABIN1741287 was sufficient for detection of NrCAM in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C
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- 抗原
- NrCAM (NRCAM) (Neuronal Cell Adhesion Molecule (NRCAM))
- 别名
- NrCAM (NRCAM 产品)
- 别名
- CD56 antibody, MSK39 antibody, NCAM antibody, Bravo antibody, C030017F07Rik antibody, C130076O07Rik antibody, mKIAA0343 antibody, NRCAM antibody, si:dkey-240a12.1 antibody, Nr-CAM antibody, neural cell adhesion molecule 1 antibody, neuronal cell adhesion molecule antibody, neuronal cell adhesion molecule L homeolog antibody, neuronal cell adhesion molecule a antibody, NCAM1 antibody, NRCAM antibody, Nrcam antibody, nrcam.L antibody, nrcama antibody, nrcam antibody
- 背景
- Neuronal cell adhesion molecule (NrCAM) is a cell surface protein of the immunoglobulin (Ig) superfamily. NrCAM (also known as Bravo) contains six Ig domains, five fibronectin repeats, a transmembrane region and an intracellular domain. NrCAM is expressed in brain, spinal cord, peripheral nervous system and pancreas. In the spinal cord, NrCAM acts as a ligand for axonin-1 to guide commissural axons across the floor plate. NrCAM also acts as a ligand for F3 to control actin-dependent growth cone motility. NrCAM interacts with neurofascin and may facilitate the clustering of the cystoskeletal protein ankyrin G and the voltage-dependent sodium channel proteins at the node of Ranvier. NrCAM expression may play a role in the severity of certain types of tumors. NrCAM is overexpressed in high-grade astrocytomas, gliomas and glioblastoma tumor tissues. In the pancreas, NrCAM expression is upregulated in intraductal hyperplasia. Antisense NrCAM reduces the tumorigenic properties of human glioblastoma cells in vitro and slowed tumor growth in vivo. The gene encoding human NrCAM maps to chromosome 7q31.1-q31.2.
- 基因ID
- 319504
- NCBI登录号
- NP_001139503
- UniProt
- Q810U4
- 途径
- Regulation of Cell Size
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