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SHANK3 抗体 (AA 538-626) (PE)

SHANK3 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S367-51 PE
产品编号 ABIN1741267
发货至: 中国
  • 抗原 See all SHANK3 抗体
    SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))
    抗原表位
    • 15
    • 10
    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 538-626
    适用
    • 43
    • 11
    • 10
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    大鼠
    宿主
    • 26
    • 21
    小鼠
    克隆类型
    • 26
    • 21
    单克隆
    标记
    • 14
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SHANK3 antibody is conjugated to PE
    应用范围
    • 31
    • 27
    • 22
    • 21
    • 17
    • 13
    • 13
    • 10
    • 8
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    Detects ~190 kDa. Cross-reacts with SHANK1. Does not cross-react with SHANK2.
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Protein G Purified
    免疫原
    Fusion protein amino acids 538-626 (SH3 domain) of rat SHANK3. Mouse: 100% identity (89/89 amino acids identical). Human: 97% identity (87/89 amino acids identical). ~70% identity with SHANK1 and SHANK2.
    克隆位点
    S367-51
    亚型
    IgG2a
    Top Product
    Discover our top product SHANK3 Primary Antibody
  • 应用备注
    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    说明

    1 μg/ml of ABIN1741267 was sufficient for detection of SHANK1/SHANK3 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Conjugated antibodies should be stored at 4°C
  • 抗原
    SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))
    别名
    SHANK3 (SHANK3 产品)
    别名
    DEL22q13.3 antibody, PROSAP2 antibody, PSAP2 antibody, SCZD15 antibody, SPANK-2 antibody, Prosap2 antibody, AI841104 antibody, Shank3b antibody, SH3 and multiple ankyrin repeat domains 3 antibody, SH3 and multiple ankyrin repeat domains protein 3 antibody, SHANK3 antibody, shank3 antibody, Shank3 antibody
    背景
    SHANK proteins are scaffolding adaptors that have been shown to integrate neurotransmitter receptors into the cortical cytoskeleton at postsynaptic densities. SHANK1-3 of the SHANK/ProSAP family are molecular scaffolds in the postsynaptic density (PSD). SHANK recruits betaPIX and PAK to dendritic spines to regulate postsynaptic structure and interacts with ionotropic receptor and metabotropic glutamate receptor complexes. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development.
    基因ID
    59312
    UniProt
    Q9JLU4
    途径
    Synaptic Membrane, Tube Formation, Regulation of long-term Neuronal Synaptic Plasticity
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