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CD11b 抗体 (AA 623-728)

Name: CD11b 抗体 (AA 623-728)
Brand: antibodies-online
SKU: ABIN1724905
Availability: OutOfStock

ITGAM 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 3A10H5 unconjugated

Western blot analysis using ITGAM mAb against human ITGAM recombinant protein. (CD11b 抗体 (AA 623-728))

Immunofluorescence analysis of Hela cells using ITGAM mouse mAb (green). (CD11b 抗体 (AA 623-728))

Western blot analysis using ITGAM mAb against HEK293 (1) and ITGAM (AA: 623-728)-hIgGFc transfected HEK293 (2) cell lysate. (CD11b 抗体 (AA 623-728))

Black line: Control Antigen (100 ng), Purple line: Antigen(10 ng), Blue line: Antigen (50 ng), Red line: Antigen (100 ng), (CD11b 抗体 (AA 623-728))

ELISA

4 images

(2 references)

产品编号 ABIN1724905

发货至: 中国

Datasheet as PDF

抗原 See all CD11b (ITGAM) 抗体

CD11b (ITGAM) (Integrin alpha M (ITGAM))
抗原表位
16

14

10

7

6

6

5

5

3

3

3

3

3

3

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 623-728
适用
252

162

60

33

17

17

16

14

11

7

7

4

4

2

2

1
人
宿主
133

104

102

2

1

1
小鼠
Compatible Secondaries
克隆类型
244

96

1
单克隆
标记
110

37

29

26

21

10

7

7

5

5

5

5

4

4

4

3

3

3

3

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1
This CD11b antibody is un-conjugated
应用范围
256

84

77

75

54

39

35

21

20

18

13

13

7

6

5

5

4

3

2

2

2

1

1
ELISA, Immunocytochemistry (ICC)

原理

ITGAM Antibody

纯化方法

Purified antibody

免疫原

Purified recombinant fragment of human ITGAM (AA: 623-728) expressed in E. Coli.

克隆位点

3A10H5

亚型

IgG1

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ITGAM 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-174 FITC

anti-Integrin alpha M (ITGAM) antibody (PE)
ITGAM 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-174 PE

应用备注

ELISA: 1/10000
ICC: 1/200 - 1/1000

限制

仅限研究用
状态

Liquid

缓冲液

Purified antibody in PBS with 0.05 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Rhodes, Fürnrohr, Roberts, Tzircotis, Schett, Spector, Vyse: "The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes." in: Annals of the rheumatic diseases, Vol. 71, Issue 12, pp. 2028-34, (2012) (PubMed).

Grüger, Reiners, Schnitzler, Brandenburg, Zündorf: "Garenoxacin-induced increase of CD11b expression on human polymorphonuclear neutrophils does not affect phagocytosis and killing of Staphylococcus aureus." in: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Vol. 17, Issue 2, pp. 291-6, (2011) (PubMed).
抗原

CD11b (ITGAM) (Integrin alpha M (ITGAM))

别名

ITGAM (ITGAM 产品)

别名

CD11b/CD18 antibody, CR3 antibody, CR3A antibody, Cd11b antibody, F730045J24Rik antibody, Ly-40 antibody, MAC1 antibody, Mac-1 antibody, Mac-1a antibody, CD11B antibody, MAC-1 antibody, MAC1A antibody, MO1A antibody, SLEB6 antibody, C3bi antibody, integrin subunit alpha M antibody, integrin alpha M antibody, integrin, alpha M (complement component 3 receptor 3 subunit) antibody, integrin alpha-M antibody, ITGAM antibody, Itgam antibody, LOC100351865 antibody

背景

Description: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.
Aliases: CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6

分子量

127.1kDa

基因ID

3684

HGNC

3684

UniProt

P11215

途径

Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation