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EGFR 抗体 (Mutant)

Name: EGFR 抗体 (Mutant)
Brand: antibodies-online
SKU: ABIN1724824
Availability: OutOfStock

EGFR 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 5G9B5 unconjugated

Western blot analysis using EGFR mutant mouse mAb against SPC-A-1 (1), A549 (2), HepG2 (3) and MCF-7 (4) cell lysate. (EGFR 抗体 (Mutant))

Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using EGFR mutant mouse mAb with DAB staining. (EGFR 抗体 (Mutant))

IHC

Black line: Control Antigen (100 ng), Purple line: Antigen(10 ng), Blue line: Antigen (50 ng), Red line: Antigen (100 ng), (EGFR 抗体 (Mutant))

ELISA

Flow cytometric analysis of HepG2 cells using EGFR mutant mouse mAb (green) and negative control (purple). (EGFR 抗体 (Mutant))

FACS

Western blot analysis using EGFR mutant mAb against human EGFR mutant recombinant protein. (EGFR 抗体 (Mutant))

Western blot analysis using EGFR mutant mAb against HEK293 (1) and EGFR mutant (AA: 693-893)-hIgGFc transfected HEK293 (2) cell lysate. (EGFR 抗体 (Mutant))

Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using EGFR mutant mouse mAb with DAB staining. (EGFR 抗体 (Mutant))

IHC

7 images

(2 references)

产品编号 ABIN1724824

发货至: 中国

Datasheet as PDF

抗原 See all EGFR 抗体

EGFR (Epidermal Growth Factor Receptor (EGFR))
抗原表位
39

38

38

38

28

27

26

26

26

21

19

18

17

16

16

16

15

15

15

15

15

13

13

13

11

9

8

7

7

6

5

5

5

4

4

4

4

4

4

4

3

3

3

3

3

3

3

3

3

3
AA 693-893, Mutant
适用
802

332

324

26

26

24

20

15

9

3

2

2

1

1

1

1

1

1
人
宿主
632

174

13

11

5

1

1
小鼠
Compatible Secondaries
克隆类型
598

234

2
单克隆
标记
424

63

31

25

22

21

20

20

20

20

20

14

10

10

10

10

10

10

10

10

10

8

8

5

4

4

4

4

4

1

1

1

1

1

1
This EGFR antibody is un-conjugated
应用范围
564

271

155

141

124

101

95

92

81

46

37

34

33

18

11

8

6

4

4

3

3

3

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

产品特性

Mutant

纯化方法

purified

免疫原

Purified recombinant fragment of human EGFR mutant (AA: 693-893) expressed in E. coli.

克隆位点

5G9B5

亚型

IgG1

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anti-Epidermal Growth Factor Receptor (EGFR) (pSer1071) antibody
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anti-Epidermal Growth Factor Receptor (EGFR) (AA 1021-1210) antibody
EGFR 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Epidermal Growth Factor Receptor (EGFR) (AA 1021-1210) antibody
EGFR 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated

anti-Epidermal Growth Factor Receptor (EGFR) (AA 693-893) antibody
EGFR 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 5E10D3 unconjugated

应用备注

ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400

限制

仅限研究用
状态

Liquid

缓冲液

Ascitic fluid containing 0.03 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C/-20 °C

储存方法

4°C, -20°C for long term storage
Derer, Bauer, Lohse, Scheel, Berger, Kellner, Peipp, Valerius: "Impact of epidermal growth factor receptor (EGFR) cell surface expression levels on effector mechanisms of EGFR antibodies." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 11, pp. 5230-9, (2012) (PubMed).

Minder, Bayha, Becker-Pauly, Sterchi: "Meprin? transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration." in: The Journal of biological chemistry, Vol. 287, Issue 42, pp. 35201-11, (2012) (PubMed).
抗原

EGFR (Epidermal Growth Factor Receptor (EGFR))

别名

EGFR (EGFR 产品)

别名

C-erb antibody, CG10079 antibody, D-EGFR antibody, D-Egf antibody, DEGFR antibody, DER antibody, DER flb antibody, DER/EGFR antibody, DER/faint little ball antibody, DER/top antibody, DER/torpedo antibody, DER1 antibody, DEgfr antibody, Degfr antibody, Der antibody, DmHD-33 antibody, Dmel\\CG10079 antibody, EFG-R antibody, EGF-R antibody, EGFR antibody, EGFr antibody, EGfr antibody, EK2-6 antibody, Egf antibody, Egf-r antibody, EgfR antibody, El antibody, Elp antibody, Elp-1 antibody, Elp-B1 antibody, Elp-B1RB1 antibody, HD-33 antibody, TOP antibody, Torpedo/DER antibody, Torpedo/Egfr antibody, c-erbB antibody, d-egf-r antibody, dEGFR antibody, dEGFR1 antibody, dEgfr antibody, der antibody, egfr antibody, flb antibody, l(2)05351 antibody, l(2)09261 antibody, l(2)57DEFa antibody, l(2)57EFa antibody, l(2)57Ea antibody, mor1 antibody, top antibody, top/DER antibody, top/flb antibody, torpedo/Egfr antibody, torpedo/egfr antibody, EGFR12 antibody, EGFR15 antibody, egfr1 antibody, Erbb2 antibody, ERBB antibody, ERBB1 antibody, HER1 antibody, PIG61 antibody, mENA antibody, ErbB-1 antibody, Errp antibody, 9030024J15Rik antibody, AI552599 antibody, Erbb antibody, Errb1 antibody, Wa5 antibody, wa-2 antibody, wa2 antibody, epidermal growth factor receptor antibody, Epidermal growth factor receptor antibody, epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) antibody, EGFR antibody, Egfr antibody, egfra antibody, egfr1 antibody, LOC5564544 antibody

背景

Description: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. ,
Aliases: ERBB, HER1, mENA, ERBB1, PIG61

分子量

175 kDa

基因ID

1956

HGNC

1956

途径

NF-kappaB Signaling, RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteins