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Integrin Alpha2b 抗体 (AA 45-149)

CD41 适用: 人 FACS, ELISA, IHC 宿主: 小鼠 Monoclonal 2E10C9 unconjugated
产品编号 ABIN1724822
发货至: 中国
  • 抗原 See all Integrin Alpha2b (CD41) 抗体
    Integrin Alpha2b (CD41)
    抗原表位
    • 16
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    • 1
    • 1
    AA 45-149
    适用
    • 120
    • 32
    • 21
    • 8
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 74
    • 48
    • 23
    小鼠
    克隆类型
    • 96
    • 43
    • 1
    单克隆
    标记
    • 59
    • 16
    • 14
    • 12
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Integrin Alpha2b antibody is un-conjugated
    应用范围
    • 101
    • 42
    • 27
    • 26
    • 21
    • 19
    • 13
    • 13
    • 9
    • 9
    • 8
    • 5
    • 2
    • 1
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    • 1
    Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC)
    原理
    ITGA2B Antibody
    纯化方法
    Ascitic fluid
    免疫原
    Purified recombinant fragment of human ITGA2B (AA: 45-149) expressed in E. Coli.
    克隆位点
    2E10C9
    亚型
    IgG1
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Park, Chung, Lee, Park, Kim, Kim: "Novel and recurrent mutations of ITGA2B and ITGB3 genes in Korean patients with Glanzmann thrombasthenia." in: Pediatric blood & cancer, Vol. 59, Issue 2, pp. 335-8, (2012) (PubMed).

    Nurden, Fiore, Nurden, Pillois: "Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models." in: Blood, Vol. 118, Issue 23, pp. 5996-6005, (2011) (PubMed).

  • 抗原
    Integrin Alpha2b (CD41)
    别名
    ITGA2B (CD41 产品)
    背景

    Description: ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

    Aliases: GT, GTA, CD41, GP2B, HPA3, CD41B, GPIIb, BDPLT2

    分子量
    113.4kDa
    基因ID
    3674
    HGNC
    3674
    UniProt
    P08514
    途径
    Integrin Complex
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