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C17orf53 抗体 (AA 282-527)

C17ORF53 适用: 人 ELISA 宿主: 小鼠 Monoclonal 5F3H1 unconjugated
产品编号 ABIN1724777
发货至: 中国
  • 抗原 See all C17orf53 (C17ORF53) products
    C17orf53 (C17ORF53) (Chromosome 17 Open Reading Frame 53 (C17ORF53))
    抗原表位
    • 5
    • 1
    • 1
    • 1
    • 1
    AA 282-527
    适用
    • 31
    • 15
    • 15
    • 3
    • 2
    • 2
    • 2
    • 1
    宿主
    • 19
    • 12
    小鼠
    克隆类型
    • 19
    • 12
    单克隆
    标记
    • 10
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This C17orf53 antibody is un-conjugated
    应用范围
    • 22
    • 13
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    ELISA
    原理
    C17ORF53 Antibody
    纯化方法
    Ascitic fluid
    免疫原
    Purified recombinant fragment of human C17ORF53 (AA: 282-527 ) expressed in E. Coli.
    克隆位点
    5F3H1
    亚型
    IgG2a
  • 应用备注
    ELISA: 1/10000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Styrkarsdottir, Halldorsson, Gretarsdottir, Gudbjartsson, Walters, Ingvarsson, Jonsdottir, Saemundsdottir, Snorradóttir, Center, Nguyen, Alexandersen, Gulcher, Eisman, Christiansen, Sigurdsson, Kong et al.: "New sequence variants associated with bone mineral density. ..." in: Nature genetics, Vol. 41, Issue 1, pp. 15-7, (2008) (PubMed).

  • 抗原
    C17orf53 (C17ORF53) (Chromosome 17 Open Reading Frame 53 (C17ORF53))
    别名
    C17ORF53 (C17ORF53 产品)
    别名
    chromosome 17 open reading frame 53 antibody, C17orf53 antibody
    背景
    C17orf53 (chromosome 17 open reading frame 53) is a 647 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

    分子量
    69.8kDa
    基因ID
    78995
    HGNC
    78995
    UniProt
    Q8N3J3
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