C17orf53 抗体 (AA 282-527)
(1 reference)-
- 抗原 See all C17orf53 (C17ORF53) products
- C17orf53 (C17ORF53) (Chromosome 17 Open Reading Frame 53 (C17ORF53))
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抗原表位
- AA 282-527
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This C17orf53 antibody is un-conjugated
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应用范围
- ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)
- 原理
- C17ORF53 Antibody
- 纯化方法
- Purified antibody
- 免疫原
- Purified recombinant fragment of human C17ORF53 (AA: 282-527) expressed in E. Coli.
- 克隆位点
- 7A3A9
- 亚型
- IgG2b
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anti-Chromosome 17 Open Reading Frame 53 (C17ORF53) (AA 282-527) antibody
C17ORF53 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 7A3A9 unconjugated
anti-Chromosome 17 Open Reading Frame 53 (C17ORF53) (AA 282-527) antibodyC17ORF53 适用: 人 ELISA 宿主: 小鼠 Monoclonal 5F3H1 unconjugated
anti-Chromosome 17 Open Reading Frame 53 (C17ORF53) (AA 282-527) antibodyC17ORF53 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3E10H2 unconjugated
anti-Chromosome 17 Open Reading Frame 53 (C17ORF53) (AA 282-527) antibodyC17ORF53 适用: 人 WB, ELISA, FACS, IF/ICC 宿主: 小鼠 Monoclonal unconjugated
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- 应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/50
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "New sequence variants associated with bone mineral density. ..." in: Nature genetics, Vol. 41, Issue 1, pp. 15-7, (2008) (PubMed).
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: "New sequence variants associated with bone mineral density. ..." in: Nature genetics, Vol. 41, Issue 1, pp. 15-7, (2008) (PubMed).
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- 抗原
- C17orf53 (C17ORF53) (Chromosome 17 Open Reading Frame 53 (C17ORF53))
- 别名
- C17ORF53 (C17ORF53 产品)
- 别名
- chromosome 17 open reading frame 53 antibody, C17orf53 antibody
- 背景
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C17orf53 (chromosome 17 open reading frame 53) is a 647 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.
- 分子量
- 69.8kDa
- 基因ID
- 78995
- HGNC
- 78995
- UniProt
- Q8N3J3
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